Summary of project PR002618

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002618. The data can be accessed directly via it's Project DOI: 10.21228/M87R8P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002618
Project DOI:doi: 10.21228/M87R8P
Project Title:Influence of valeric acid fermentation on metabolites of human fecal microbial community
Project Summary:By using an in vitro simulated intestinal fermentation system, the influence of valeric acid on the metabolites of the microbial community was investigated. Results: Notable differential metabolites included Isotocin, Isoleucyl-Lysine, and D-glutamine. Sankey diagram analysis further demonstrated the involvement of Deoxyadenosine, Xanthine, and Adenine in enriched pathways such as ABC transporters, purine metabolism, and nucleotide metabolism. Comparative analysis between the PMV and PS groups revealed 177 upregulated and 157 downregulated metabolites. Agmatine and specific amino acids emerged as common differential metabolites in both PS-vs-Control and PMV-vs-PS comparisons. The findings indicate that arginine metabolism serves as a critical regulatory target of valeric acid.
Institute:Zhejiang University
Last Name:Yan
First Name:Fujie
Address:Yuhangtang Road, Hangzhou, Zhejiang, 310058, China
Email:fjyan@zju.edu.cn
Phone:+86 15068185696

Summary of all studies in project PR002618

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST004156 Valerate maintains ammonia homeostasis through modulating microbial amino acid metabolism Homo sapiens Zhejiang University MS* 2025-09-22 1 24 Uploaded data (3.4G)*
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