Summary of project PR002622
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002622. The data can be accessed directly via it's Project DOI: 10.21228/M8QR9D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002622 |
| Project DOI: | doi: 10.21228/M8QR9D |
| Project Title: | Distinct plasma metabolomic alterations are associated with physical function, weight loss, and muscle mass in men with cancer |
| Project Summary: | Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials. By reflecting downstream effects of cellular function, metabolomics may identify mechanisms contributing to poor functional performance. Previous metabolomic studies in cancer cachexia have identified alterations in amino acid metabolism with weight loss or low muscularity; none have examined perturbations with poor physical function. We hypothesized that distinct metabolic signals in plasma and muscle are associated with weight loss, low muscle mass, and impaired function in cancer cachexia. Our studies find that significant metabolomic alterations in plasma and skeletal muscle characterized cancer-related weight loss and reduced CSA, respectively. Nominal, function-specific alterations were detected with worse HGS and SCP which were distinct from those associated with weight loss or low CSA. Future larger studies may further characterize metabolomic profiles related to various functional outcomes and guide development of therapeutic targets to improve functional performance. |
| Institute: | VA Puget Sound Health Care System |
| Last Name: | Anderson |
| First Name: | Lindsey |
| Address: | 1660 S. Columbian Way (S-182-GRECC), Seattle, WA, 98108, USA |
| Email: | lindsey.anderson5@va.gov |
| Phone: | 206-277-6719 |
Summary of all studies in project PR002622
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004161 | Distinct plasma metabolomic alterations are associated with physical function, weight loss, and muscle mass in men with cancer | Homo sapiens | VA Puget Sound Health Care System | MS | 2025-09-25 | 1 | 88 | Uploaded data (1.4G)* |
