Summary of project PR002629
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002629. The data can be accessed directly via it's Project DOI: 10.21228/M8TK1K This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002629 |
| Project DOI: | doi: 10.21228/M8TK1K |
| Project Title: | Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer |
| Project Summary: | The aim was to compare how alanine is metabolized in MYC-driven liver tumors versus non-tumor liver tissue. Liver tumor bearing mice were infused with C13/N15 alanine, and kidney, liver tumor, and non tumor liver tissue were harvested. Kidney was used as an internal positive control, since the kidney is a known site of alanine metabolism. We found that on average ~35% of the tumor alanine pool had at least one heavy isotope label, thus confirming the efficacy of our tracing strategy. We uncovered a repertoire of pathways downstream of alanine, with multiple metabolites being preferentially labelled in tumor versus non-tumor tissue. Among the pathways fed by alanine in tumors were metabolites relating to cellular bioenergetics, biosynthesis, and the oxidative stress response. Thus our study identified how alanine is a substrate for metabolism in MYC-driven liver tumors. |
| Institute: | University of California, San Francisco |
| Department: | Cell & Tissue Biology |
| Last Name: | Montoya |
| First Name: | Tonatiuh |
| Address: | 513 Parnassus Ave |
| Email: | Tonatiuh.Montoya@ucsf.edu |
| Phone: | 415-476-4187 |
Summary of all studies in project PR002629
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004169 | Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer | Mus musculus | University of California, San Francisco | MS | 2026-01-12 | 1 | 21 | Uploaded data (2.1G)* |
