Summary of project PR002645
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002645. The data can be accessed directly via it's Project DOI: 10.21228/M8RN9P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002645 |
| Project DOI: | doi: 10.21228/M8RN9P |
| Project Title: | High Fluoride Exposure Disrupts Gut Microbiota and Induces Intestinal Barrier Damage via RhoA/ROCK-Mediated Cytoskeletal Remodeling |
| Project Summary: | Fluoride is an environmental pollutant that causes intestinal barrier damage, but the role of the "gut microbiota-RhoA/ROCK-cytoskeleton" axis in this process remains unclear. The aim of this project is to investigate the damage mechanism of high fluoride exposure on the intestinal barrier in mice. Focusing on the core objective of how high fluoride affects the intestinal barrier through the gut microbiota-mediated "RhoA/ROCK - cytoskeleton remodeling" axis, the study combines metagenomic approaches and leverages untargeted metabolomic analysis to reveal the gut microbiota dysbiosis and significant changes in intestinal metabolites induced by high fluoride. It clarifies the variation of cytoskeleton-related differential metabolites and screens out the key bacterial species that are strongly associated with the phenotypic characteristics of intestinal barrier damage, cytoskeletal core proteins, key tight junction proteins, and RhoA/ROCK pathway molecules in mice. In doing so, this research provides a new perspective for studying the mechanism of fluoride-induced intestinal barrier damage and lays a foundation for the prevention of fluoride-related intestinal diseases. |
| Institute: | Sichuan Agricultural University |
| Department: | College Of Veterinary Medicine |
| Laboratory: | Animal Microecology Institute, Sichuan Agricultural University |
| Last Name: | DanDan |
| First Name: | Wang |
| Address: | Huimin Road, Wenjiang District, Chengdu, Sichuan, 611100, China |
| Email: | 1150784177@qq.com |
| Phone: | 17656691293 |
Summary of all studies in project PR002645
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004196 | High fluoride exposure disrupts the intestinal microbiota and induces intestinal barrier damage | Mus musculus | Animal Microecology Institute, Sichuan Agricultural University | MS* | 2025-10-08 | 1 | 18 | Uploaded data (3.4G)* |
