Summary of project PR002673
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002673. The data can be accessed directly via it's Project DOI: 10.21228/M84P1D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002673 |
| Project DOI: | doi: 10.21228/M84P1D |
| Project Title: | Chain length-dependent mobilization and oxidation of fatty acids in adipocytes |
| Project Summary: | Fatty acids (FAs) are essential metabolites in energy homeostasis. Adipocytes store FAs as triacylglycerol (TG) in their lipid droplets and mobilize them upon demand in order to provide energy for peripheral tissues. While the mobilization of long-chain fatty acids (LCFAs) during lipolysis is largely documented, there is little information on the metabolism of short- and medium-chain fatty acids (SMCFA) in adipocytes. We demonstrate that adipocytes store SMCFAs in their lipid droplets and that following lipolysis initiation, TGs containing SMCFAs undergo rapid hydrolysis. We found that this process is facilitated by the preferential accumulation of SMCFA-containing TGs at the surface of lipid droplets, thereby enhancing their accessibility to lipases. Unlike LCFAs, SMCFAs are not released from the adipocytes following lipolysis but undergo oxidation within the cell. Our findings suggest that SMCFAs are preferentially mobilized and oxidized to provide energy for the adipocyte, highlighting a distinct metabolic fate compared to LCFAs. |
| Institute: | University of Szeged |
| Department: | Institute of Biochemistry |
| Last Name: | Kovacs |
| First Name: | David |
| Address: | Dóm tér 9, Szeged, Csongrád-Csanád, 6723, Hungary |
| Email: | kovacs.david@med.u-szeged.hu |
| Phone: | +3662342665 |
Summary of all studies in project PR002673
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004236 | Lipidomics analysis of TERT-hWA adipocytes spheroids under basal and stimulated lipolysis conditions | Homo sapiens | University of Szeged | MS | 2025-10-20 | 1 | 60 | Uploaded data (10.3G)* |
| ST004237 | Lipidomic analysis of the perigonadal adipose tissue of Control, HSL KO and ATGL KO mice. | Mus musculus | University of Szeged | MS | 2025-10-20 | 1 | 48 | Uploaded data (6.3G)* |
| ST004238 | Lipidomic Characterization of Wild-Type vs ATGL/HSL Double Knockout Adipocytes in Basal and Stimulated Lipolysis | Mus musculus | University of Szeged | MS | 2025-10-20 | 1 | 48 | Uploaded data (5.3G)* |
