Summary of project PR002674

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002674. The data can be accessed directly via it's Project DOI: 10.21228/M80Z6T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002674
Project DOI:doi: 10.21228/M80Z6T
Project Title:The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations
Project Summary:This project aims to develop and validate a blood-based biomarker model to identify individuals at elevated risk of asthma exacerbations. Global metabolomics highlighted steroid, sphingolipid, and microbiome-linked metabolic pathways as associated with asthma status and exacerbation risk. Targeted quantification showed that sphingolipid-to-steroid ratios were strongly and consistently associated with 5‑year risk of exacerbation. Derived a simple predictive model based on 21 sphingolipid-to-steroid ratios that replicated across cohorts and outperformed current clinical measures (discovery AUC = 0.90; replication AUC = 0.89). These findings underscore the value of metabolomic profiling to develop a practical, cost-effective clinical assay for asthma exacerbation risk that may improve patient care.
Institute:China Pharmaceutical University
Last Name:Pei
First Name:Zhang
Address:#24 Tongjia Rd. Gulou District, Nanjing, China
Email:peizhang@cpu.edu.cn
Phone:+8602583271021

Summary of all studies in project PR002674

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST004241 Global metabolomics and lipidomics identified steroid, sphingolipid, and microbiome-associated pathways linked to asthma exacerbation Homo sapiens China Pharmaceutical University MS* 2025-10-20 1 3420 Uploaded data (184.3G)*
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