Summary of project PR002705
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002705. The data can be accessed directly via it's Project DOI: 10.21228/M80V75 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002705 |
| Project DOI: | doi: 10.21228/M80V75 |
| Project Title: | Impact of alcohol exposure on the liver and brain lipidomes of mice with experimental alcohol-associated liver disease |
| Project Type: | Original research |
| Project Summary: | Alcohol-associated liver disease (ALD) has imposed a substantial public health burden in the United States, and alcohol consumption induces systemic lipid dysregulation in ALD. To investigate this, the lipidomes of liver and brain tissues from alcohol-fed (AF) and pair-fed (PF) mice were characterized by comprehensive two-dimensional liquid chromatography-mass spectrometry. Multiple database matching was used for high-confidence lipid identification. Univariable and multivariable analyses were employed to identify lipids with significantly altered abundance between AF and PF mice. Furthermore, differential correlation analysis and cross-tissue co-dysregulation mapping were performed. Our data indicated that alcohol feeding induced profound tissue-specific lipidomic alterations. Triglycerides increased significantly, and phospholipids decreased in the livers of alcohol-treated mice, whereas their brains exhibited elevation of oxidized lipids with subclass-divergent changes in glycerolipids, glycerophospholipids, and sphingolipids. Differential correlation analysis revealed extensive remodeling of lipid interaction networks in the alcohol-exposed brain. Cross-tissue analysis identified 18 co-dysregulated lipids demonstrating a strongly correlated lipid regulation shift in AF mice. Collectively, alcohol rewires organ-specific lipidomes through distinct mechanisms and induces correlated multi-tissue lipid dysregulation, suggesting potential lipid-centric communication along the liver-brain axis. These findings provide novel insights into ALD pathogenesis and reveal potential biomarkers for multi-organ involvement. |
| Institute: | University of Louisville |
| Department: | Chemistry |
| Laboratory: | Dr. Xiang Zhang lab |
| Last Name: | Feng |
| First Name: | Jing |
| Address: | 2210 S brook St. Louisville, KY 40208 |
| Email: | jing.feng@louisville.edu |
| Phone: | 5026187846 |
| Funding Source: | This work was supported by NIH [1P20GM113226 (CJM); 1P50AA024337 (CJM); 1U01AA026934 (CJM); 1U01AA026926 (CJM); 1U01AA026980 (CJM); 1R21AA031563 (LH); and S10OD020106 (XZ)]. This work was also supported by the Department of Veterans Affairs, 1I01BX002996-01A2 (CJM). |
| Publications: | Journal of Proteome Research, Submitted |
| Contributors: | Yuan Fang |
Summary of all studies in project PR002705
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004281 | 2DLC-MS-based lipidomics of alcohol-associated liver disease mouse liver and brain | Mus musculus | University of Louisville | MS | 2026-01-02 | 1 | 30 | Uploaded data (16.2G)* |
