Summary of project PR002711
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002711. The data can be accessed directly via it's Project DOI: 10.21228/M87C30 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002711 |
| Project DOI: | doi: 10.21228/M87C30 |
| Project Title: | Investigation on the spaceflight-induced phenotypic changes and potential mechanisms of Bacillus Licheniformis |
| Project Summary: | Bacillus licheniformis (BL) is a common probiotic clinically used to treat acute and chronic enteritis and diarrhea. The present study aimed to investigate the phenotypic changes and potential mechanisms of BL after a 6-month spaceflight aboard the China Space Station based on characterization test, morphological observation and multi-omics analysis. 6-month spaceflight delayed BL growth curve, reduced its cell wall thickness, and impaired BL biofilm formation ability and adhesion capacity to Caco-2 cells. BL viability at pH 9.0 was decreased by 9.42%. In the 6-month spaceflight BL, proteomics revealed 164 of differentially expressed proteins mainly involved on DNA damage, ATP binding, helicase activity. Metabolomics identified 55 of significantly altered metabolites, and whole-genome sequencing detected five mutated genes. After 6-month spaceflight, physiological characteristics of BL were significantly changed. Various proteins, metabolites and genes were dramatically altered as well. These novel findings may provide new insights into adaptive evolution of BL under long-term space environment, which is expected to benefit for further clinical application of BL. |
| Institute: | Beijing Institute of Technology |
| Last Name: | shen |
| First Name: | shuyan |
| Address: | Beijing Institute of Technology, Zhongguancun Campus, beijing, China, 100081, China |
| Email: | 1819599261@qq.com |
| Phone: | 18526251633 |
Summary of all studies in project PR002711
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004294 | Investigation on the spaceflight-induced phenotypic changes and potential mechanisms of Bacillus Licheniformis | Bacillus licheniformis | Beijing Institute of Technology | MS | 2025-11-06 | 1 | 24 | Uploaded data (2.7G)* |
