Summary of project PR002718
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002718. The data can be accessed directly via it's Project DOI: 10.21228/M8B26Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002718 |
| Project DOI: | doi: 10.21228/M8B26Z |
| Project Title: | Metabolomic analysis of wild-type and TauT-/- murine Mesenchymal Stromal Cells (MSCs) |
| Project Summary: | Bone marrow mesenchymal stromal cells (BMSCs) are a type of multipotent stem cell found in the bone marrow stroma that can differentiate into various cell types, support the bone marrow's microenvironment, and regulate other stem cells. Their key functions include providing physical support to hematopoietic stem cells, secreting factors that control their homeostasis, and undergoing differentiation into bone, cartilage, and fat cells. BMSCs are also being explored for various cell therapies due to their ability to be expanded in vitro. To determine the role of taurine in regulating metabolism of bone marrow mesenchymal stromal cells (MSCs), we carried out untargeted metabolomic analysis of murine taurine transporter (TauT) wild-type and knockout MSCs. Briefly, 16 week old TauT+/+ and TauT-/- mice were sacrificed, stromal populations were isolated and magnetically enriched or flow sorted for MSCs. Next, untargeted metabolomic analysis was carried out to identify metabolic changes induced by inhibiting taurine uptake in MSCs. This analysis identified inositol metabolism as a downstream effector of taurine in MSCs. |
| Institute: | University of Rochester Medical Center |
| Last Name: | Smith |
| First Name: | Bradley |
| Address: | 575 Elmwood Ave, Rochester, NY, 14620 |
| Email: | bradley_smith@urmc.rochester.edu |
| Phone: | 585-275-1445 |
Summary of all studies in project PR002718
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004302 | Metabolomic analysis of wild-type and TauT-/- murine Mesenchymal Stromal Cells (MSCs) | Mus musculus | University of Rochester Medical Center | MS* | 2025-11-12 | 1 | 10 | Uploaded data (854.2M)* |
