Summary of project PR002737
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002737. The data can be accessed directly via it's Project DOI: 10.21228/M8VZ6K This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002737 |
| Project DOI: | doi: 10.21228/M8VZ6K |
| Project Title: | Human Hearts intrinsically increase cardiomyocyte mitosis following myocardial infarction |
| Project Type: | Metabolomics |
| Project Summary: | Background: Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes (CMs) within the human heart. Although CMs undergo mitosis during early development, most CMs cease cell cycling soon after birth. In contrast, rodent MI models have shown that CMs increase mitosis in response to ischemia, however this has not been shown in humans. Methods: Using a unique pre-mortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human CM mitosis post-MI. Results: We show that adult human CMs exhibit increased mitosis and cytokinesis in response to ischemia. Conclusions: Future development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration. |
| Institute: | University of Sydney |
| Department: | Charles Perkins Centre |
| Laboratory: | Centre for Heart Failure and Diseases of the Aorta |
| Last Name: | Robert |
| First Name: | Hume |
| Address: | John Hopkins Dr, Camperdown, NSW 2050, Australia |
| Email: | robert.hume@sydney.edu.au |
| Phone: | 0434848772 |
| Publications: | Circulation Research (in print) |
Summary of all studies in project PR002737
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004323 | Human Hearts intrinsically increase cardiomyocyte mitosis following myocardial infarction | Homo sapiens | University of Sydney | MS | 2025-12-01 | 1 | 34 | Uploaded data (8.1M)* |
