Summary of project PR002796
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002796. The data can be accessed directly via it's Project DOI: 10.21228/M87V8Q This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002796 |
| Project DOI: | doi: 10.21228/M87V8Q |
| Project Title: | Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum |
| Project Summary: | Malaria is a deadly parasitic disease for which innovative treatments are urgently needed. A mixture of eight triterpenic esters (8TTE) was previously identified as important for the antiplasmodial activity of Keetia leucantha twigs, a plant used in traditional medicine in Benin. Thus, 8TTE thus appears as a promising natural product for developing new antimalarial therapeutic strategies against P. falciparum; however, despite the reported in vitro and in vivo activity, the targets of 8TTE are unknown. This study investigated the mode of action of 8TTE on Plasmodium falciparum by a multi-scale integrative study from phenotype to metabolome, including phenotypic analysis, enzymatic tests, molecular docking and metabolomic profiling. This study identified a unique antiplasmodial profile with activity onset in the early-ring stage of the parasite, the inhibition of aminopeptidase PfA-M17 (PlasmoDB PF3D7_1446200), and perturbations in parasite hemoglobin metabolism. Further structure-activity and medicinal chemistry studies are warranted to elaborate on our findings and the potential for 8TTE-related molecules to serve as future antimalarial drugs. |
| Institute: | Pennsylvania State University |
| Department: | Biochemistry and Molecular Biology |
| Laboratory: | Manuel Llinás |
| Last Name: | Rangel |
| First Name: | Gabriel |
| Address: | 491 Pollock Road, University Park, PA, 16802, USA |
| Email: | grangel0955@gmail.com |
| Phone: | 8148673527 |
Summary of all studies in project PR002796
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004425 | Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum | Plasmodium falciparum | Pennsylvania State University | MS | 2025-12-29 | 1 | 45 | Uploaded data (1.5G)* |
