Summary of project PR002798
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002798. The data can be accessed directly via it's Project DOI: 10.21228/M80C2F This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002798 |
| Project DOI: | doi: 10.21228/M80C2F |
| Project Title: | Brief Pulses of High-Level Fluid Shear Stress Enhance Metastatic Potential and Rapidly Alter the Metabolism of Cancer Cells |
| Project Type: | GC-and LC-MS |
| Project Summary: | Circulating tumor cells (CTCs) face challenges to their survival including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade are not well understood. Here we find that cancer cells (PC-3, MDA-MB-231, Myc-CaP) exposed to brief pulses of high-level FSS exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling and contractility as well as reducing equivalents to counter oxidative stress associated with cell detachment. Thus, exposure to FSS may provide CTCs an unexpected survival benefit that promotes metastatic colonization. |
| Institute: | Eastern Virginia Medical School at Old Dominion University |
| Department: | Department of Biomedical & Translational Sciences |
| Laboratory: | Dr. Michael Henry |
| Last Name: | Henry |
| First Name: | Michael |
| Address: | 700 W Olney Rd, PO Box 1980, Norfolk, VA, 23501 |
| Email: | mhenry@odu.edu |
| Phone: | 757-446-5619 |
| Funding Source: | NIH |
| Publications: | doi: https://doi.org/10.1101/2025.04.09.647247 |
| Contributors: | Amanda N Pope, Devon L Moose, Eric B Taylor |
Summary of all studies in project PR002798
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004427 | Brief Pulses of High-Level Fluid Shear Stress Enhance Metastatic Potential and Rapidly Alter the Metabolism of Cancer Cells | Homo sapiens | Eastern Virginia Medical School at Old Dominion University | MS | 2025-12-29 | 1 | 63 | Uploaded data (3.9G)* |
