Summary of project PR002800
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002800. The data can be accessed directly via it's Project DOI: 10.21228/M8QV7P This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002800 |
| Project DOI: | doi: 10.21228/M8QV7P |
| Project Title: | Metabolomic profiling of NMNAT2–SARM1 pathway modulation in mouse cortical neurodegeneration |
| Project Summary: | Neuronal NAD⁺ depletion via NMNAT2 loss reprograms brain metabolism toward fatty-acid oxidation, lipid depletion, and oxidative stress. Multi-omics profiling (untargeted metabolomics and lipidomics) of NMNAT2 conditional knockout and SARM1-deleted mouse cortex revealed coordinated changes in glycolysis, redox cofactors, and lipid pathways. Complete SARM1 deletion restored metabolic and lipid balance, supporting the NMNAT2–SARM1 axis as a key regulator of neuronal and glial metabolism. |
| Institute: | Indiana University Bloomington |
| Last Name: | Niou |
| First Name: | Zhen-Xian |
| Address: | 400 EAST SEVENTH STREET, BLOOMINGTON, IN, 47405, USA |
| Email: | niouz@iu.edu |
| Phone: | 7022097321 |
Summary of all studies in project PR002800
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004432 | Metabolomic profiling of NMNAT2–SARM1 pathway modulation in mouse cortical neurodegeneration | Mus musculus | Indiana University Bloomington | MS | 2026-01-02 | 1 | 25 | Uploaded data (4.4G)* |
