Summary of project PR002820
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002820. The data can be accessed directly via it's Project DOI: 10.21228/M84Z8T This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002820 |
| Project DOI: | doi: 10.21228/M84Z8T |
| Project Title: | Microbial Ecology-Guided Discovery of Antibacterial Drugs |
| Project Summary: | The project aims to discover antibiotics and characterize their mechanisms of action. We investigate proteobacteria that live symbiotically with animals as the source of the antibiotics. Specifically, bacteria live in the gills of shipworm mollusks, providing the cellulases needed for the mollusks to consume wood in the sea. The bacteria also contain large numbers of biosynthetic pathways for potential antibiotics, at least some of which are secreted into the animals where they likely act to impact the symbiosis. Because the antibiotics are made and secreted on animals, they are less likely to have direct impacts on animal cells. Among early hit compounds discovered, turnercyclamycins are lipodedpsipeptides that kill many multidrug-resistant, Gram-negative pathogens with clinical relevance. One of the goals of our project is to understand how turnercyclamycins work to kill bacteria that are resistant to other lipopeptide antibiotics, such as colistin. Here, we have studied this by comparing the impacts of colistin and turneryclamycin on bacterial membranes and the phospholipidome. By performing these and related studies on antibiotics produced by symbiotic bacteria, their mechanisms of action are unveiled. |
| Institute: | University of Utah |
| Last Name: | Schmidt |
| First Name: | Eric |
| Address: | 30 South 2000 East Room 307 Salt Lake City UT 84112 |
| Email: | ews1@utah.edu |
| Phone: | +1-801-585-5234 |
Summary of all studies in project PR002820
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004466 | Differential mechanisms of membrane lipid disruption by antibiotic lipopeptides colistin and turnercyclamycins | Escherichia coli | University of Utah | MS | 2026-01-06 | 1 | 72 | Uploaded data (2.1G)* |
