Summary of project PR002825
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002825. The data can be accessed directly via it's Project DOI: 10.21228/M8H555 This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002825 |
| Project DOI: | doi: 10.21228/M8H555 |
| Project Title: | Responsiveness to 2’FL and GOS by infant gut microbiota differs by history of individual 2’FL consumption |
| Project Summary: | Background: The microbiota strongly influences human gut homeostasis and health through its metabolites. The metabolic products of the infant microbiota are strongly influenced by human milk or formula feeding. Human milk contains oligosaccharides (HMOS) that are prebiotic, promoting gut colonization by mutualists. Most human milk contains 2’-fucosyllactose (2’FL) as its principal oligosaccharide, but its abundance varies. The goal of this study was to evaluate the metabolites of cultured stool microbiota in the presence of different prebiotics as an approach to predict prebiotic responsiveness. Our studies find that The response to 2’FL or GOS in baseline fermentation analysis was associated with differences in microbial beta-diversity, suggesting that individual responsiveness to specific prebiotics may be predicted by anaerobic fermentation of their stool samples. Continuous supplementation of prebiotic may prime the gut microbiota to more efficiently utilize this prebiotic. |
| Institute: | University of Cincinnati College of Medicine |
| Last Name: | Thorman |
| First Name: | Alexander |
| Address: | 160 Panzeca Way 125 Kettering Lab Complex, Cincinnati, OH, 45220, USA |
| Email: | thormaaw@ucmail.uc.edu |
| Phone: | 513-746-5121 |
Summary of all studies in project PR002825
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004478 | Responsiveness to 2’FL and GOS by infant gut microbiota differs by history of individual 2’FL consumption | Homo sapiens | University of Cincinnati College of Medicine | NMR | 2026-01-06 | 1 | 522 | Uploaded data (470.6M)* |
