Summary of project PR002858
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002858. The data can be accessed directly via it's Project DOI: 10.21228/M87K2P This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002858 |
| Project DOI: | doi: 10.21228/M87K2P |
| Project Title: | Lipidomics studies of Mycoplasma gallisepticum cells and vesicles |
| Project Summary: | The question of how a living cell functions—specifically, how it regulates and adapts to stress—has intrigued scientists for many years. While the established concept of bacterial regulation centers on genomic and transcriptomic levels, this framework cannot fully explain stress responses in mycoplasmas, which are widely regarded as a model of a minimal cell. In this study, we have demonstrated that the key mechanism of stress response in a minimal cell is the reduction of cellular volume through the release of the attachment organelle ("tip") in the form of vesicles. This process leads to a metabolic reorganization within the cell and an accumulation of ATP. Metabolic adaptation is achieved by altering the stoichiometric ratio of glycolytic proteins and modulating the local concentration of metabolites, both of which affect the rate of glycolysis. On the other hand, the vesicles themselves—which carry VlhA, lipoproteins, adhesins, hydrogen-peroxide-secreting factors, and possess peptidase activity—can actively participate in the infectious process. The obtained results will advance not only our understanding of mycoplasma pathogenesis but also the comprehension of minimal cell organization, which is crucial for creating its synthetic counterpart. |
| Institute: | Research Institute for Systems Biology and Medicine (RISBM) |
| Last Name: | Matyushkina |
| First Name: | Daria |
| Address: | 18 Nauchny proezd, Moscow, 117246, Russia. |
| Email: | d.matyushkina@sysbiomed.ru |
| Phone: | +7-916-327-09-05 |
Summary of all studies in project PR002858
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004534 | Lipidomics studies of Mycoplasma gallisepticum cells and vesicles. Minimal cell - regulation of metabolism by size variation. | Mycoplasma gallisepticum | Research Institute for Systems Biology and Medicine (RISBM) | MS* | 2026-01-20 | 1 | 18 | Uploaded data (107.6M)* |
