Summary of study ST000017

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Study IDST000017
Study TitleRat HCR/LCR Stamina Study
Study TypeLC-MS analysis (Untargeted)
Study SummaryMaximal exercise-associated oxidative capacity is strongly correlated with health and longevity in humans. Rats selectively bred for high running capacity (HCR) have improved metabolic health and are longer-lived than their low-capacity counterparts (LCR). Using metabolomic and proteomic profiling, we show that HCR efficiently oxidize fatty acids (FAs) and branched-chain amino acids (BCAAs), sparing glycogen and reducing accumulation of short- and medium-chain acylcarnitines. HCR mitochondria have reduced acetylation of mitochondrial proteins within oxidative pathways at rest, and there is rapid protein deacetylation with exercise, which is greater in HCR than LCR. Fluxomic analysis of valine degradation with exercise demonstrates a functional role of differential protein acetylation in HCR and LCR. Our data suggest that efficient FA and BCAA utilization contribute to high intrinsic exercise capacity and the health and longevity benefits associated with enhanced fitness. Research is published, untargeted data not used in publication but project description is relevant:
InstituteUniversity of Michigan
DepartmentInternal Medicine
LaboratoryBurant Lab (MMOC)
Last NameQi
First NameNathan
Submit Date2013-09-24
Num Groups2
Total Subjects42
Raw Data AvailableYes
Raw Data File Type(s)*.xml
Uploaded File Size6.8 M
Release Date2013-10-24
Release Version1

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Project ID:PR000016
Project DOI:doi: 10.21228/M86P45
Project Title:Rat Stamina Studies
Project Type:Feeding
Project Summary:Stamina in rats
Institute:University of Michigan
Department:Internal Medicine
Laboratory:Burant Lab
Last Name:Beecher
First Name:Chris
Funding Source:NIH: R01 DK077200