Summary of study ST000090

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000082. The data can be accessed directly via it's Project DOI: 10.21228/M8Z30M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000090
Study TitleCaloric Restriction vs drugs
Study TypeComparison of caloric restriction vs medications that prolong life (Untargeted)
Study SummaryRapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug. Some of the endocrine and metabolic changes seen in diet-restricted mice are not seen in mice exposed to rapamycin, and the pattern of expression of hepatic genes involved in xenobiotic metabolism is also quite distinct in rapamycin-treated and diet-restricted mice, suggesting that these two interventions for extending mouse lifespan differ in many respects. Research is published, untargeted data not used in publication but project description is relevant: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Email mkachman@umich.edu
Submit Date2014-07-16
Num Groups5
Total Subjects70
Raw Data AvailableYes
Raw Data File Type(s).cd,.cG,.bin,.xml,.stg,.
Uploaded File Size24 G
Analysis Type DetailLC-MS
Release Date2014-07-30
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8Z30M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000082
Project DOI:doi: 10.21228/M8Z30M
Project Title:Caloric restriction Studies
Project Summary:Caloric restriction vs medications that prolong life
Institute:University of Michigan
Department:UMich Internal Medicine
Laboratory:Burant Lab
Last Name:Beecher
First Name:Chris
Email:chrisbee@med.umich.edu
Phone:734-232-0815
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