Summary of study ST000105

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000097. The data can be accessed directly via it's Project DOI: 10.21228/M8HS3M This work is supported by NIH grant, U2C- DK119886.

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Study IDST000105
Study TitleSCOR Metabolomics
Study TypeMen, control women and PCOS women w/ and w/o OSA. (Untargeted)
Study SummaryPolycystic ovary syndrome (PCOS) affects between 5% and 8% of women, making it one of the most common endocrinopathies in women. The disorder typically has its onset at puberty with evidence of excessive androgen production, obesity, and insulin resistance. Women with PCOS are more insulin resistant than weight-matched controls and have an exceptionally high prevalence of early-onset impaired glucose tolerance (30-40%), and type 2 diabetes (up to 10%). Over the past several years, chronic decreases in sleep duration and/or quality have been identified as a risk for the development of a number of metabolic derangements that are strikingly similar to those seen in PCOS. Specifically, decreased sleep quality due to obstructive sleep apnea (OSA) has been causally linked to insulin resistance, glucose intolerance, dyslipidemia and hypertension independent of body mass index (BMI). Until recently, however, it had not been recognized that OSA is present in a disproportionate number of women with PCOS: the risk for OSA is at least 5- to 10-fold higher compared to the risk in similarly obese women without PCOS. The causes and consequences of OSA in women with PCOS are addressed in this manuscript. Research is NOT published, but project description is relevant: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279609/
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Email mkachman@umich.edu
Submit Date2014-09-30
Num Groups19
Total Subjects112
Raw Data AvailableYes
Raw Data File Type(s).xml,.loG,.stg,
Uploaded File Size8.8 M
Analysis Type DetailLC-MS
Release Date2015-02-03
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8HS3M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000097
Project DOI:doi: 10.21228/M8HS3M
Project Title:Sex, Steroids, Sleep and Metabolic Dysfunction in Women
Project Summary:Gender obstructive sleep apnea studies
Institute:University of Chicago
Department:Medicine/EDM
Laboratory:Ehrmann/Van Cauter Lab
Last Name:Ehrmann
First Name:David
Address:Chicago, IL
Email:dehrmann@uchicago.edu
Phone:773-702-3334
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