Summary of study ST000249

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000201. The data can be accessed directly via it's Project DOI: 10.21228/M8DK5C This work is supported by NIH grant, U2C- DK119886.

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Study IDST000249
Study TitleMeasurement of free amino acid (AA) in response to MYC
Study Typetreatment
Study SummaryThe proposed study will provide us information how the different AAs are affected by MYC. MYC is known to cause increased levels of glutamin due to import and synthesis, but we hypothesize that the overall pool of free AA in the cells is reduced, especially when cells are starved.
Institute
University of Florida
DepartmentSECIM
Last NameSchaub
First NameFranz
EmailFranz.Schaub@moffitt.org
Submit Date2015-09-22
Num Groups2
Total Subjects6
Raw Data AvailableNo
Analysis Type DetailLC-MS
Release Date2016-09-23
Release Version1
Franz Schaub Franz Schaub
https://dx.doi.org/10.21228/M8DK5C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000201
Project DOI:doi: 10.21228/M8DK5C
Project Title:Myc-directed suppression of autophagy provides therapeutic vulnerabilities targeting amino acid homeostasis
Project Type:Targeted LCMS Metabolomics
Project Summary:Hypothesis:MYC is suppressing the autophagy pathway which leads to impaired recycling of proteins and reduced free AA in the cells.
Institute:Moffitt Cancer Center
Department:Tumor Biology
Laboratory:John Cleveland
Last Name:Cleveland
First Name:John
Address:12902 Magnolia Dr,Tampa, FL 33612
Phone:813 745 3888
Funding Source:NIH
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