Summary of study ST000282

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000224. The data can be accessed directly via it's Project DOI: 10.21228/M8K599 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000282
Study TitlePilot Study 13C flux effects when RhoC or RhoA perturbed (13C BCs)
Study Type13C mass isotopomer analysis (flux studies)
Study SummaryRho-GTPases are small GTP-binding proteins that contribute to the epithelial-to-mesenchymal transition by regulating several cellular processes including organization of the actin cytoskeleton, cell motility, transcription, and cell proliferation. Overexpression of RhoC-GTPases (RhoC) in breast cancer has been implicated in poor disease prognosis due to increased cancer cells invasion, migration, and motility, which warranted its consideration as a therapeutic target for inhibiting breast cancer metastasis. Using silencing RNA (siRNA) molecules to knockdown RhoC expression is a promising approach to inhibit breast cancer metastases.
University of Michigan
DepartmentInternal Medicine
LaboratoryMerajver Lab
Last NameWynn
First NameMichelle
AddressUniversity Michigan, 2900 Huron Parkway, Ann Arbor, MI 48105
Submit Date2015-02-11
Num Groups5
Total Subjects16
Analysis Type DetailGC/LC-MS
Release Date2016-01-13
Release Version1
Michelle Wynn Michelle Wynn application/zip

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Project ID:PR000224
Project DOI:doi: 10.21228/M8K599
Project Title:13C mass isotopomer analysis
Project Summary:Pilot studies before designing future experiments
Institute:University of Michigan
Department:Internal Medicine
Laboratory:Merajver Lab
Last Name:Merajver
First Name:Sophia
Address:University Michigan, 2900 Huron Parkway, Ann Arbor, MI 48105