Summary of study ST000378

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000297. The data can be accessed directly via it's Project DOI: 10.21228/M8NP5K This work is supported by NIH grant, U2C- DK119886.

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Study IDST000378
Study Title2 hydroxiglutarate with with IDH1-R132H inhibitor in neurospheres
Study TypeRegular
Study SummaryTumor neurospheres carrying genetic lession NPI (NRAS, shP53, IDH1-R132H) colony 1 and 2 (C1 and C2); NPAI (NRAS, shP53, shATRX, IDH1-R132H) colony 1 and 2 (C1 and C2); and NPA (NRAS, shP53, shATRX) (C1 and C2). Was treated with IDH1-R132H inhibitor. By 2HG assay we want to check the effect of the inhibitor in our cells.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2016-04-20
Num Groups3
Total Subjects12
Study Comments(shATRX) : ATRX knockdown sequence into a Sleeping Beauty (SB) transposase-responsive plasmid
Raw Data AvailableYes
Raw Data File Type(s).bin, .xsd, .xml
Analysis Type DetailLC-MS
Release Date2016-12-22
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8NP5K
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000297
Project DOI:doi: 10.21228/M8NP5K
Project Title:IDH1(R132H) mutations activity in neurospheres
Project Summary:assay 2HG procution in neurospheres expressing IDH1 mutated
Institute:University of Michigan
Department:Neurosurgery
Laboratory:Castro Lab
Last Name:Castro
First Name:Maria
Address:Ann Arbor, MI
Email:mariacas@umich.edu
Phone:734-764-0850
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