Summary of Study ST000706
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000503. The data can be accessed directly via it's Project DOI: 10.21228/M8ND66 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000706 |
| Study Title | Effect of DASH Diet on Gut Microbiome (SCFA from stool) |
| Study Type | MS analysis |
| Study Summary | This research will examine the effect of the currently recommended DASH diet versus a Vegetarian DASH diet on the gut microbiome and risk for cardiovascular disease in pre-hypertensive obese African American women. We will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction. |
| Institute | University of Michigan |
| Department | Biomedical Research Core Facilities |
| Laboratory | Metabolomics core |
| Last Name | Kachman |
| First Name | Maureen |
| Address | 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 |
| mkachman@med.umich.edu | |
| Phone | (734) 232-8175 |
| Submit Date | 2017-06-19 |
| Num Groups | 5 |
| Total Subjects | 13 |
| Study Comments | We will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction. |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | GC-MS |
| Release Date | 2017-12-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR000503 |
| Project DOI: | doi: 10.21228/M8ND66 |
| Project Title: | Effect of DASH Diet on Gut Microbiome |
| Project Type: | MS analysis |
| Project Summary: | Effect of DASH Diet on Gut Microbiome |
| Institute: | Morehouse School of Medicine |
| Department: | Clinical Research Center |
| Laboratory: | Umeakunne Lab |
| Last Name: | Umeakunne |
| First Name: | Kayellen |
| Address: | Atlanta, GA |
| Email: | kumeakunne@msm.edu |
| Phone: | 404-752-1010 |
Subject:
| Subject ID: | SU000729 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Species Group: | Mammals |
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | GROUP | Timepoint |
|---|---|---|---|
| SA039893 | S00019911 | pre-hypertensive | Baseline |
| SA039894 | S00019913 | pre-hypertensive | Baseline |
| SA039895 | S00019912 | pre-hypertensive | Final |
| SA039896 | S00019914 | pre-hypertensive | Final |
| SA039892 | S00020331 | - | - |
| SA039897 | S00019922 | vegetarian | NA |
| SA039898 | S00019923 | vegetarian | NA |
| SA039899 | S00019921 | vegetarian | NA |
| SA039900 | S00019924 | vegetarian | NA |
| SA039901 | S00019918 | vegetarian | NA |
| SA039902 | S00019915 | vegetarian | NA |
| SA039903 | S00019916 | vegetarian | NA |
| SA039904 | S00019917 | vegetarian | NA |
| SA039905 | S00019919 | vegetarian | NA |
| SA039906 | S00019920 | vegetarian | NA |
| Showing results 1 to 15 of 15 |
Collection:
| Collection ID: | CO000723 |
| Collection Summary: | - |
| Sample Type: | Feces |
Treatment:
| Treatment ID: | TR000743 |
| Treatment Summary: | - |
Sample Preparation:
| Sampleprep ID: | SP000736 |
| Sampleprep Summary: | - |
| Sampleprep Protocol Filename: | A007_-_Short_Chain_Fatty_Acids.pdf |
Chromatography:
| Chromatography ID: | CH000771 |
| Instrument Name: | Agilent 7890N |
| Column Name: | Phenomenex Zebron ZB-WAXplus (30m x 0.25mm,0.25um) |
| Chromatography Type: | GC |
Analysis:
| Analysis ID: | AN001097 |
| Analysis Type: | MS |
| Analysis Protocol File: | A007_-_Short_Chain_Fatty_Acids.pdf |
| Instrument Name: | GC_7890N MS_5975 (Agilent) |
| Chromatography ID: | CH000771 |
| Num Factors: | 4 |
| Num Metabolites: | 7 |
| Units: | nmol/mg |
