Summary of study ST000775

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000561. The data can be accessed directly via it's Project DOI: 10.21228/M8539W This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000775
Study TitleMichigan Biomarkers for Refractory Depression (Bluebird) metabolomics pilot study
Study TypeMS analysis
Study SummaryThe goal of the project is discovery of clinical useful biomarkers for treatment-resistant depression. All participants were undergoing electroconvulsive therapy (ECT) for treatment-resistant depression (major depressive disorder or bipolar disorder) in 2012-2014. All subjects were Caucasian except BB060, who was Asian. Samples were collected from each subject at baseline just before the first ECT treatment (Time Point T0) and approximately 3 weeks later just before the tenth ECT treatment (Time Point T2). Whole blood was drawn in the morning in a fasted state (at least 7 hours) through an intravenous catheter or butterfly needle into 6-mL EDTA tubes (Lavender Top, Becton Dickinson Vacutainer K2EDTA additive blood collection tube, part #367863) and transported to the processing lab at the Michigan Clinical Research Unit within 30 minutes. Plasma was isolated by centrifugation for 10 minutes at 2000G at 4C. Plasma from multiple tubes was pooled and aliquotted in 200 uL volumes into 2-mL screw-cap cryovials and frozen at -80C.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups29
Total Subjects17
Raw Data AvailableYes
Raw Data File Type(s).d
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8539W
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR000561
Project DOI:doi: 10.21228/M8539W
Project Title:Michigan Biomarkers for Refractory Depression (Bluebird)
Project Type:MS analysis
Project Summary:Discovery of clinical useful biomarkers for treatment-resistant depression
Institute:University of Michigan
Department:Psychiatry
Laboratory:Mickey Lab
Last Name:Mickey
First Name:Brian
Address:Ann Arbor, MI
Email:bmickey@umich.edu
Phone:734-647-8239

Subject:

Subject ID:SU000798
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Human

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Pair Timepoint Treatment response
SA042318S00017715Pair 1 T0 No
SA042319S00017717Pair 1 T0 Yes
SA042320S00017716Pair 1 T2 No
SA042321S00017718Pair 1 T2 Yes
SA042322S00017719Pair 2 T0 No
SA042323S00017721Pair 2 T0 Yes
SA042324S00017720Pair 2 T2 No
SA042325S00017722Pair 2 T2 Yes
SA042326S00017723Pair 3 T0 No
SA042327S00017725Pair 3 T0 Yes
SA042328S00017724Pair 3 T2 No
SA042329S00017726Pair 3 T2 Yes
SA042330S00017727Pair 4 T0 No
SA042331S00017729Pair 4 T0 Yes
SA042332S00017728Pair 4 T2 No
SA042333S00017730Pair 4 T2 Yes
SA042334S00017731Pair 5 T0 No
SA042335S00017733Pair 5 T0 Yes
SA042336S00017732Pair 5 T2 No
SA042337S00017734Pair 5 T2 Yes
SA042338S00017735Pair 6 T0 No
SA042339S00017737Pair 6 T0 Yes
SA042340S00017736Pair 6 T2 No
SA042341S00017738Pair 6 T2 Yes
SA042342S00017739Pair 7 T0 No
SA042343S00017741Pair 7 T0 Yes
SA042344S00017740Pair 7 T2 No
SA042345S00017742Pair 7 T2 Yes
SA042346S00017743Pair 8 T0 No
SA042347S00017745Pair 8 T0 Yes
SA042348S00017744Pair 8 T2 No
SA042349S00017746Pair 8 T2 Yes
SA042350S00020147Pooled Pooled Pooled
Showing results 1 to 33 of 33

Collection:

Collection ID:CO000792
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000812
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000805
Sampleprep Summary:-
Sampleprep Protocol Filename:A003_-_Untargeted_Metabolomics.pdf

Combined analysis:

Analysis ID AN001222 AN001223 AN001224 AN001225
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent Agilent Shimadzu CTO-20A Nexera X2 Shimadzu CTO-20A Nexera X2
Column Waters Acquity HSS T3 (50 x 2.1mm, 1.8um) Waters Acquity HSS T3 (50 x 2.1mm, 1.8um) Waters Acquity HSS T3 (50 x 2.1mm, 1.8um) Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF Triple TOF Triple TOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode NEGATIVE POSITIVE NEGATIVE POSITIVE
Units peak area peak area peak area normalized peak area normalized

Chromatography:

Chromatography ID:CH000858
Instrument Name:Agilent
Column Name:Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH000859
Instrument Name:Shimadzu CTO-20A Nexera X2
Column Name:Waters Acquity HSS T3 (50 x 2.1mm, 1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS001117
Analysis ID:AN001222
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
  
MS ID:MS001118
Analysis ID:AN001223
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
  
MS ID:MS001119
Analysis ID:AN001224
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:NEGATIVE
  
MS ID:MS001120
Analysis ID:AN001225
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:POSITIVE
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