Summary of study ST000955

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000656. The data can be accessed directly via it's Project DOI: 10.21228/M8W39D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000955
Study TitleEffects of ODC inhibition on T cell metabolism
Study Typedrug treatment at two time
Study SummaryIsolated T cells were activated for 48-72 hours in the presence and absence of 5mM DFMO, an ODC inhibitor
Institute
University of Florida
DepartmentSECIM
Last NameHesterberg
First NameRebecca
Address12902 Magnolia Dr
Emailrebecca.hesterberg@moffitt.org
Phone813-270-9181
Submit Date2018-04-14
Num Groups4
Total Subjects16
Study CommentsOT-1 mice express a transgenic T cell receptor in all CD8+ T cells that binds with high affinity to a peptide derived from the protein ovalbumin (SIINFEKL).
Raw Data AvailableYes
Raw Data File Type(s).raw
Analysis Type DetailLC-MS
Release Date2019-05-15
Release Version1
Rebecca Hesterberg Rebecca Hesterberg
https://dx.doi.org/10.21228/M8W39D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000656
Project DOI:doi: 10.21228/M8W39D
Project Title:Cereblon suppression offers novel approach for anti-tumor immunity in melanoma
Project Type:Exploratory
Project Summary:The functional suppression of T cells in the tumor are intimately linked to impared cellular metabolism. Glucose acts as the primary fuel source for the generation of ATP in activated T cells and both oxidative phosphorylation and glycolysis are critical for full effector functions and tumor erradication. We have identified a checkpoint protein that regulates the metabolic suppression in the tumor. Identification of the precise function of different metabolic events regulated by this checkpoint protein will be informative. This project will define the role of a glutamine/arginine mediated pathway in CD8+ T-cells.
Institute:Moffitt Cancer Center
Department:Immunology
Laboratory:Burnette
Last Name:Burnette
First Name:Pearlie
Address:12902 Magnolia Drive, Tampa, FL 33612
Email:Pearlie.Burnette@moffitt.org
Phone:813-270-9181
Funding Source:Moffitt Cancer Center
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