Summary of study ST001322

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000899. The data can be accessed directly via it's Project DOI: 10.21228/M8GQ40 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001322
Study TitleMaternal adiposity alters the human milk metabolome: a link between non-glucose monosaccharides and infant adiposity
Study Typeuntargeted metabolomics
Study SummaryAn untargeted metabolomics analysis of human milk was performed to test the hypothesis that a unique human milk metabolome would emerge based on maternal adiposity (maternal fat mass and body mass index). This study also aimed to identify differentially expressed milk metabolites that are associated with fat mass in the infant. To our knowledge this study reports on the largest cohort to date examining the metabolomic differences in human milk composition between normal weight and obese women. Data generated from this study indicate the need for further research in the area of human milk metabolomics and the potential role for human milk small molecules in contributing to offspring growth and development.
Institute
University of California, Davis
DepartmentWest Coast Metabolomics Center
Last NamePaglia
First NameKelly
Address451 Health Sciences Drive, Room 1313, Davis, CA, 95616, USA
Emailkpaglia@ucdavis.edu
Phone5307528129
Submit Date2020-02-25
Raw Data AvailableYes
Analysis Type DetailGC-MS
Release Date2020-03-17
Release Version1
Kelly Paglia Kelly Paglia
https://dx.doi.org/10.21228/M8GQ40
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR000899
Project DOI:doi: 10.21228/M8GQ40
Project Title:Maternal adiposity alters the human milk metabolome: a link between non-glucose monosaccharides and infant adiposity
Project Type:metabolomics
Project Summary:An untargeted metabolomics analysis of human milk was performed to test the hypothesis that a unique human milk metabolome would emerge based on maternal adiposity (maternal fat mass and body mass index). This study also aimed to identify differentially expressed milk metabolites that are associated with fat mass in the infant. To our knowledge this study reports on the largest cohort to date examining the metabolomic differences in human milk composition between normal weight and obese women. Data generated from this study indicate the need for further research in the area of human milk metabolomics and the potential role for human milk small molecules in contributing to offspring growth and development.
Institute:University of California, Davis
Department:West Coast Metabolomics Center
Last Name:Paglia
First Name:Kelly
Address:451 Health Sciences Drive, Room 1313, Davis, CA, 95616, USA
Email:kpaglia@ucdavis.edu
Phone:5307528129

Subject:

Subject ID:SU001396
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id treatment group
SA095582ex-173_354expecting 2 month - human breast milk OB
SA095583ex-175_355expecting 2 month - human breast milk OB
SA095584ex-181_357expecting 2 month - human breast milk OB
SA095585ex-172_353expecting 2 month - human breast milk OB
SA095586ex-177_356expecting 2 month - human breast milk OB
SA095587ex-168_351expecting 2 month - human breast milk OB
SA095588ex-163_348expecting 2 month - human breast milk OB
SA095589ex-164_349expecting 2 month - human breast milk OB
SA095590ex-166_350expecting 2 month - human breast milk OB
SA095591ex-183_358expecting 2 month - human breast milk OB
SA095592ex-171_352expecting 2 month - human breast milk OB
SA095593ex-186_360expecting 2 month - human breast milk OB
SA095594ex-200_367expecting 2 month - human breast milk OB
SA095595ex-201_368expecting 2 month - human breast milk OB
SA095596ex-202_369expecting 2 month - human breast milk OB
SA095597ex-103_323expecting 2 month - human breast milk OB
SA095598ex-199_366expecting 2 month - human breast milk OB
SA095599ex-194_365expecting 2 month - human breast milk OB
SA095600ex-161_347expecting 2 month - human breast milk OB
SA095601ex-191_362expecting 2 month - human breast milk OB
SA095602ex-192_363expecting 2 month - human breast milk OB
SA095603ex-193_364expecting 2 month - human breast milk OB
SA095604ex-184_359expecting 2 month - human breast milk OB
SA095605ex-187_361expecting 2 month - human breast milk OB
SA095606ex-116_330expecting 2 month - human breast milk OB
SA095607ex-117_331expecting 2 month - human breast milk OB
SA095608ex-119_332expecting 2 month - human breast milk OB
SA095609ex-120_333expecting 2 month - human breast milk OB
SA095610ex-109_328expecting 2 month - human breast milk OB
SA095611ex-108_327expecting 2 month - human breast milk OB
SA095612ex-156_346expecting 2 month - human breast milk OB
SA095613ex-104_324expecting 2 month - human breast milk OB
SA095614ex-106_325expecting 2 month - human breast milk OB
SA095615ex-107_326expecting 2 month - human breast milk OB
SA095616ex-123_334expecting 2 month - human breast milk OB
SA095617ex-115_329expecting 2 month - human breast milk OB
SA095618ex-146_343expecting 2 month - human breast milk OB
SA095619ex-142_342expecting 2 month - human breast milk OB
SA095620ex-147_344expecting 2 month - human breast milk OB
SA095621ex-127_335expecting 2 month - human breast milk OB
SA095622ex-154_345expecting 2 month - human breast milk OB
SA095623ex-135_340expecting 2 month - human breast milk OB
SA095624ex-137_341expecting 2 month - human breast milk OB
SA095625ex-129_337expecting 2 month - human breast milk OB
SA095626ex-130_338expecting 2 month - human breast milk OB
SA095627ex-128_336expecting 2 month - human breast milk OB
SA095628ex-134_339expecting 2 month - human breast milk OB
SA095629ex-168_303expecting 2 week - human breast milk OB
SA095630ex-167_302expecting 2 week - human breast milk OB
SA095631ex-173_304expecting 2 week - human breast milk OB
SA095632ex-181_307expecting 2 week - human breast milk OB
SA095633ex-163_300expecting 2 week - human breast milk OB
SA095634ex-177_306expecting 2 week - human breast milk OB
SA095635ex-175_305expecting 2 week - human breast milk OB
SA095636ex-154_295expecting 2 week - human breast milk OB
SA095637ex-182_308expecting 2 week - human breast milk OB
SA095638ex-153_294expecting 2 week - human breast milk OB
SA095639ex-155_296expecting 2 week - human breast milk OB
SA095640ex-156_297expecting 2 week - human breast milk OB
SA095641ex-157_298expecting 2 week - human breast milk OB
SA095642ex-161_299expecting 2 week - human breast milk OB
SA095643ex-202_321expecting 2 week - human breast milk OB
SA095644ex-199_318expecting 2 week - human breast milk OB
SA095645ex-197_317expecting 2 week - human breast milk OB
SA095646ex-200_319expecting 2 week - human breast milk OB
SA095647ex-201_320expecting 2 week - human breast milk OB
SA095648ex-152_293expecting 2 week - human breast milk OB
SA095649ex-204_322expecting 2 week - human breast milk OB
SA095650ex-195_316expecting 2 week - human breast milk OB
SA095651ex-194_315expecting 2 week - human breast milk OB
SA095652ex-187_311expecting 2 week - human breast milk OB
SA095653ex-184_310expecting 2 week - human breast milk OB
SA095654ex-191_312expecting 2 week - human breast milk OB
SA095655ex-192_313expecting 2 week - human breast milk OB
SA095656ex-193_314expecting 2 week - human breast milk OB
SA095657ex-183_309expecting 2 week - human breast milk OB
SA095658ex-166_301expecting 2 week - human breast milk OB
SA095659ex-119_273expecting 2 week - human breast milk OB
SA095660ex-116_271expecting 2 week - human breast milk OB
SA095661ex-120_274expecting 2 week - human breast milk OB
SA095662ex-121_275expecting 2 week - human breast milk OB
SA095663ex-127_277expecting 2 week - human breast milk OB
SA095664ex-123_276expecting 2 week - human breast milk OB
SA095665ex-115_270expecting 2 week - human breast milk OB
SA095666ex-114_269expecting 2 week - human breast milk OB
SA095667ex-104_264expecting 2 week - human breast milk OB
SA095668ex-151_292expecting 2 week - human breast milk OB
SA095669ex-106_265expecting 2 week - human breast milk OB
SA095670ex-107_266expecting 2 week - human breast milk OB
SA095671ex-109_268expecting 2 week - human breast milk OB
SA095672ex-108_267expecting 2 week - human breast milk OB
SA095673ex-128_278expecting 2 week - human breast milk OB
SA095674ex-117_272expecting 2 week - human breast milk OB
SA095675ex-142_287expecting 2 week - human breast milk OB
SA095676ex-137_286expecting 2 week - human breast milk OB
SA095677ex-144_288expecting 2 week - human breast milk OB
SA095678ex-146_289expecting 2 week - human breast milk OB
SA095679ex-150_291expecting 2 week - human breast milk OB
SA095680ex-129_279expecting 2 week - human breast milk OB
SA095681ex-103_263expecting 2 week - human breast milk OB
Showing page 1 of 4     Results:    1  2  3  4  Next     Showing results 1 to 100 of 386

Collection:

Collection ID:CO001391
Collection Summary:The breast milk was frozen at -70C upon arrival. At a later date, the milk was thawed, aliquoted and refrozen at -70C until time for shipment.
Sample Type:Breast

Treatment:

Treatment ID:TR001411
Treatment Summary:There are 2 groups and 3 time points., At 2 weeks, there are 160 samples. At 2 months, there are 132 samples. At 6 months, there are 94 samples, There is breast milk from normal weight and obese mothers at each time point.

Sample Preparation:

Sampleprep ID:SP001404
Sampleprep Summary:The breast milk was frozen at -70C upon arrival. At a later date, the milk was thawed, aliquoted and refrozen at -70C until time for shipment.

Combined analysis:

Analysis ID AN002198
Analysis type MS
Chromatography type GC
Chromatography system Leco Pegasus IV GC
Column Restek Rtx-5Sil MS (30 x 0.25mm, 0.25um)
MS Type EI
MS instrument type QTOF
MS instrument name Leco Pegasus IV TOF
Ion Mode POSITIVE
Units normalized peak height

Chromatography:

Chromatography ID:CH001612
Instrument Name:Leco Pegasus IV GC
Column Name:Restek Rtx-5Sil MS (30 x 0.25mm, 0.25um)
Chromatography Type:GC

MS:

MS ID:MS002044
Analysis ID:AN002198
Instrument Name:Leco Pegasus IV TOF
Instrument Type:QTOF
MS Type:EI
MS Comments:A Leco Pegasus IV time of flight mass spectrometer is controlled by the Leco ChromaTOF software vs. 2.32 (St. Joseph, MI). The transfer line temperature between gas chromatograph and mass spectrometer is set to 280°C. Electron impact ionization at 70V is employed with an ion source temperature of 250°C. Acquisition rate is 17 spectra/second, with a scan mass range of 85-500 Da.
Ion Mode:POSITIVE
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