Summary of Study ST001378

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000943. The data can be accessed directly via it's Project DOI: 10.21228/M8ST1P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Study ID	ST001378
Study Title	Global metabolomics of COPD2020
Study Summary	To discover distinctive endogenous metabotype of patients with COPD associated with TB from those originated from Tabaco smoking. Cross-sectional metabolomic analyses of serum samples were performed for subjects including TB-associated COPD (T-COPD), smoking-associated COPD (S-COPD) and healthy subjects. To retain a broad spectrum of metabolites, technically distinct analyses (global metabolomic profiling using liquid chromatography quadrupole time-of-flight mass spectrometry) were employed. Frozen samples were diluted with either an acetonitrile:methanol:water (3:3:4) mixture. Each sample (5 μL) was loaded onto an C18 column and was analyzed using an Agilent 6530 QTOF mass spectrometer (Agilent Technologies). Detailed protocol is obtained in this project
Institute	Seoul National University Hospital
Last Name	Kim
First Name	Da jung
Address	Daehak-ro 101, Seoul, South Korea
Email	dkim3193@snu.ac.kr
Phone	+82100
Submit Date	2020-05-05
Raw Data Available	Yes
Raw Data File Type(s)	d
Analysis Type Detail	LC-MS
Release Date	2020-11-15
Release Version	1

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Project:

Project ID:	PR000943
Project DOI:	doi: 10.21228/M8ST1P
Project Title:	COPD_2020
Project Summary:	To discover distinctive endogenous metabotype of patients with COPD associated with TB from those originated from Tabaco smoking. Cross-sectional metabolomic analyses of serum samples were performed for subjects including TB-associated COPD (T-COPD), smoking-associated COPD (S-COPD) and healthy subjects. To retain a broad spectrum of metabolites, technically distinct analyses (global metabolomic profiling using liquid chromatography quadrupole time-of-flight mass spectrometry) were employed.
Institute:	Seoul National University Hospital
Last Name:	KIM
First Name:	DA JUNG
Address:	Daehak-ro 101, Seoul, South Korea
Email:	dkim3193@snu.ac.kr
Phone:	+82100

Subject:

Subject ID:	SU001452
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606
Species Group:	Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	Diagnosis
SA100698	COPD_35	COPD
SA100699	COPD_36	COPD
SA100700	COPD_34	COPD
SA100701	COPD_33	COPD
SA100702	COPD_32	COPD
SA100703	COPD_37	COPD
SA100704	COPD_39	COPD
SA100705	COPD_42	COPD
SA100706	COPD_43	COPD
SA100707	COPD_41	COPD
SA100708	COPD_40	COPD
SA100709	COPD_31	COPD
SA100710	COPD_38	COPD
SA100711	COPD_30	COPD
SA100712	COPD_22	COPD
SA100713	COPD_23	COPD
SA100714	COPD_21	COPD
SA100715	COPD_20	COPD
SA100716	COPD_19	COPD
SA100717	COPD_24	COPD
SA100718	COPD_25	COPD
SA100719	COPD_29	COPD
SA100720	COPD_28	COPD
SA100721	COPD_27	COPD
SA100722	COPD_26	COPD
SA100723	COPD_44	COPD
SA100724	COPD_46	COPD
SA100725	COPD_63	COPD
SA100726	COPD_64	COPD
SA100727	COPD_62	COPD
SA100728	COPD_61	COPD
SA100729	COPD_60	COPD
SA100730	COPD_65	COPD
SA100731	COPD_66	COPD
SA100732	COPD_70	COPD
SA100733	COPD_71	COPD
SA100734	COPD_69	COPD
SA100735	COPD_68	COPD
SA100736	COPD_67	COPD
SA100737	COPD_59	COPD
SA100738	COPD_58	COPD
SA100739	COPD_50	COPD
SA100740	COPD_51	COPD
SA100741	COPD_49	COPD
SA100742	COPD_47	COPD
SA100743	COPD_18	COPD
SA100744	COPD_52	COPD
SA100745	COPD_53	COPD
SA100746	COPD_57	COPD
SA100747	COPD_56	COPD
SA100748	COPD_55	COPD
SA100749	COPD_54	COPD
SA100750	COPD_45	COPD
SA100751	COPD_48	COPD
SA100752	COPD_07	COPD
SA100753	COPD_08	COPD
SA100754	COPD_03	COPD
SA100755	COPD_02	COPD
SA100756	COPD_17	COPD
SA100757	COPD_01	COPD
SA100758	COPD_09	COPD
SA100759	COPD_06	COPD
SA100760	COPD_14	COPD
SA100761	COPD_15	COPD
SA100762	COPD_10	COPD
SA100763	COPD_13	COPD
SA100764	COPD_16	COPD
SA100765	COPD_12	COPD
SA100766	COPD_11	COPD
SA100767	NC_15	NC
SA100768	NC_13	NC
SA100769	NC_12	NC
SA100770	NC_16	NC
SA100771	NC_18	NC
SA100772	NC_20	NC
SA100773	NC_19	NC
SA100774	NC_11	NC
SA100775	NC_17	NC
SA100776	NC_02	NC
SA100777	NC_04	NC
SA100778	NC_03	NC
SA100779	NC_21	NC
SA100780	NC_05	NC
SA100781	NC_06	NC
SA100782	NC_09	NC
SA100783	NC_08	NC
SA100784	NC_07	NC
SA100785	NC_10	NC
SA100786	NC_14	NC
SA100787	NC_34	NC
SA100788	NC_33	NC
SA100789	NC_32	NC
SA100790	NC_31	NC
SA100791	NC_35	NC
SA100792	NC_37	NC
SA100793	NC_22	NC
SA100794	NC_39	NC
SA100795	NC_38	NC
SA100796	NC_30	NC
SA100797	NC_36	NC

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Collection:

Collection ID:	CO001447
Collection Summary:	Serum samples of COPD, TOPD and normal control
Sample Type:	Blood (serum)

Treatment:

Treatment ID:	TR001467
Treatment Summary:	No treatment required

Sample Preparation:

Sampleprep ID:	SP001460
Sampleprep Summary:	Frozen samples were thawed at 4 °C, and 50 μL of each sample was diluted with 80% methanol (high-performance liquid chromatography grade, Millipore, Bedford, MA, USA).

Chromatography:

Chromatography ID:	CH001688
Instrument Name:	Agilent 1290 Infinity
Column Name:	Waters Acquity BEH C18 (100 x 2mm,1.7um)
Chromatography Type:	Reversed phase

Analysis:

Analysis ID:	AN002298
Analysis Type:	MS
Chromatography ID:	CH001688
Num Factors:	3
Num Metabolites:	9
Rt Units:	Minutes
Units:	log(relative intensity)