Summary of Study ST001727

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001107. The data can be accessed directly via it's Project DOI: 10.21228/M8MD78 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001727
Study TitleMetabolomics and metagenomics of metformin (Plasma)
Study SummaryMetformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute
Seoul National University
DepartmentDepartment of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Last NameLee
First NameYujin
Address101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Emailyoojinlee@snu.ac.kr
Phone+821033804686
Submit Date2021-03-16
Raw Data AvailableYes
Raw Data File Type(s)smp
Analysis Type DetailGC-MS
Release Date2021-08-31
Release Version1
Yujin Lee Yujin Lee
https://dx.doi.org/10.21228/M8MD78
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001107
Project DOI:doi: 10.21228/M8MD78
Project Title:Metabolomics and metagenomics of metformin (Plasma)
Project Summary:Metformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute:Seoul National University
Department:Department of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Laboratory:Metabolomics analysis lab
Last Name:Lee
First Name:Yujin
Address:101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Email:yoojinlee@snu.ac.kr
Phone:+821033804686

Subject:

Subject ID:SU001804
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Gender Race Group
SA162501R204-P1Male Asian Control
SA162502R202-P1Male Asian Control
SA162503R201-P1Male Asian Control
SA162504R205-P1Male Asian Control
SA162505R207-P1Male Asian Control
SA162506R101-P1Male Asian Control
SA162507R210-P1Male Asian Control
SA162508R114-P1Male Asian Control
SA162509R206-P1Male Asian Control
SA162510R203-P1Male Asian Control
SA162511R106-P1Male Asian Control
SA162512R105-P1Male Asian Control
SA162513R113-P1Male Asian Control
SA162514R102-P1Male Asian Control
SA162515R107-P1Male Asian Control
SA162516R103-P1Male Asian Control
SA162517R109-P1Male Asian Control
SA162518R112-P1Male Asian Control
SA162519R111-P1Male Asian Control
SA162520R110-P1Male Asian Control
SA162521R203-P2Male Asian Treated
SA162522R202-P2Male Asian Treated
SA162523R201-P2Male Asian Treated
SA162524R204-P2Male Asian Treated
SA162525R207-P2Male Asian Treated
SA162526R114-P2Male Asian Treated
SA162527R210-P2Male Asian Treated
SA162528R206-P2Male Asian Treated
SA162529R205-P2Male Asian Treated
SA162530R101-P2Male Asian Treated
SA162531R106-P2Male Asian Treated
SA162532R105-P2Male Asian Treated
SA162533R103-P2Male Asian Treated
SA162534R102-P2Male Asian Treated
SA162535R107-P2Male Asian Treated
SA162536R109-P2Male Asian Treated
SA162537R112-P2Male Asian Treated
SA162538R111-P2Male Asian Treated
SA162539R110-P2Male Asian Treated
SA162540R113-P2Male Asian Treated
Showing results 1 to 40 of 40

Collection:

Collection ID:CO001797
Collection Summary:We recruited and included 20 healthy adult male subjects.
Sample Type:Blood (plasma)

Treatment:

Treatment ID:TR001817
Treatment Summary:The subjects received oral metformin 1000mg twice daily.

Sample Preparation:

Sampleprep ID:SP001810
Sampleprep Summary:The samples were extracted twice.

Combined analysis:

Analysis ID AN002812
Analysis type MS
Chromatography type GC
Chromatography system Agilent 7890B
Column Restek Rtx-5Sil (30m x 0.25mm,0.25um)
MS Type EI
MS instrument type GC-TOF
MS instrument name Leco Pegasus HT TOF
Ion Mode NEGATIVE
Units intensity

Chromatography:

Chromatography ID:CH002077
Instrument Name:Agilent 7890B
Column Name:Restek Rtx-5Sil (30m x 0.25mm,0.25um)
Chromatography Type:GC

MS:

MS ID:MS002606
Analysis ID:AN002812
Instrument Name:Leco Pegasus HT TOF
Instrument Type:GC-TOF
MS Type:EI
MS Comments:Leco chroma TOF-GC Software v4.
Ion Mode:NEGATIVE
  logo