Summary of Study ST001754

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001115. The data can be accessed directly via it's Project DOI: 10.21228/M8KD8B This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001754
Study TitleMetabolomic Analysis of Canine Diabetes (part-II)
Study TypeSingle time point blood collection
Study SummaryBlood was collected from diabetic dogs and healthy control dogs. Diabetic dogs and control dogs were breed matched where possible. Timing of blood collection after a meal was matched as best as posible. Serum was frozen at -80C.
University of Florida
Last NameO'Kell
First NameAllison
Address2015 SW 16th Ave
Submit Date2021-04-01
Num Groups2
Total Subjects30
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2021-10-29
Release Version1
Allison O'Kell Allison O'Kell application/zip

Select appropriate tab below to view additional metadata details:


Project ID:PR001115
Project DOI:doi: 10.21228/M8KD8B
Project Title:Utility of canine diabetes as a model for human type 1 diabetes (part-I)
Project Summary:We are examining the etiopathogenesis of canine diabetes to determine the relevance of these animals as a naturally occurring model of human type 1 diabetes. We will undertake phenotypic, metabolic, and immunologic investigations in diabetic dogs to better characterize their diabetes and attempt to identify potential biomarkers of a pre-diabetic state.
Institute:University of Florida
Department:Diabetes Institute (Wasserfall/Atkinson)/College of Veterinary Medicine (O'Kell)
Last Name:O'Kell
First Name:Allison
Address:2015 SW 16th Ave


Subject ID:SU001831
Subject Type:Mammal
Subject Species:Canis lupus familiaris
Taxonomy ID:9615


Subject type: Mammal; Subject species: Canis lupus familiaris (Factor headings shown in green)

mb_sample_id local_sample_id Diabetic or Healthy Sex Fasted or Fed Breed
SA163962327679Diabetic MI Fed Labrador retriever
SA163963325419Diabetic MN Fasted Bichon Frise
SA163964354675Diabetic MN Fasted Maltese
SA163965346336Diabetic MN Fasted Mix (Jack Russell Terrier)
SA163966349833Diabetic MN Fasted Pomeranian
SA163967353791Diabetic MN Fasted Silky Terrier
SA163968319373Diabetic MN Fed Cavalier King Charles Spaniel
SA163969308098Diabetic MN Fed Miniature Australian Shepherd
SA163970333987Diabetic MN Fed Mix (Pug/beagle)
SA163971348332Diabetic MN Fed Rottweiler
SA163972313074Diabetic SF Fasted Miniature Pinscher
SA163973329649Diabetic SF Fasted Mix
SA163974355594Diabetic SF Fasted Mix
SA163975349937Diabetic SF Fasted Rottweiler
SA163976242045Diabetic SF Fed Miniature Schnauzer
SA163977301154Healthy MN Fasted Maltese mix
SA163978309999Healthy MN Fasted Rottweiler
SA163979280189Healthy MN Fed Labrador retriever
SA163980328335Healthy MN Fed Miniature Australian Shepherd
SA163981232368Healthy MN Fed Mix (Beagle)
SA163982295509Healthy MN Fed Rottweiler
SA163983292894Healthy SF Fasted Bichon/Poodle
SA163984344481Healthy SF Fasted Miniature Pinscher
SA163985243765Healthy SF Fasted Mix
SA163986355837Healthy SF Fasted Mix
SA163987298006Healthy SF Fasted Mix (Jack Russell Terrier)
SA163988360399Healthy SF Fasted Pomeranian
SA163989359130Healthy SF Fasted Silky Terrier
SA163990277908Healthy SF Fed Cavalier King Charles Spaniel
SA163991274821Healthy SF Fed Miniature Schnauzer
Showing results 1 to 30 of 30


Collection ID:CO001824
Collection Summary:Blood collected by peripheral venipuncture into red top tube (containing clot activator). Blood was allowed to clot, then centrifuged at 2000 g x 7.5 minutes between 20-30 minutes after sample collection. Serum was frozen immediately after separation (always within 1 hour of collection) at -80 C.
Sample Type:Blood (serum)


Treatment ID:TR001844
Treatment Summary:None for research study. Variable medications may have been received by diabetic dogs. Healthy dogs are only allowed to receive flea/tick/heartworm preventatives.

Sample Preparation:

Sampleprep ID:SP001837
Sampleprep Summary:see protocol attached
Sampleprep Protocol Filename:Protein_Precipitation_Sample_Prep.pdf

Combined analysis:

Analysis ID AN002857 AN002858
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Thermo Dionex Ultimate 3000 RS Thermo Dionex Ultimate 3000 RS
Column ACE Excel 2 C18-PFP (100 x 2.1mm, 2um) ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
MS instrument type Orbitrap Orbitrap
MS instrument name Thermo Exactive Plus Orbitrap Thermo Exactive Plus Orbitrap
Units Peak Height Peak Height


Chromatography ID:CH002116
Chromatography Summary:see attached
Instrument Name:Thermo Dionex Ultimate 3000 RS
Column Name:ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
Chromatography Type:Reversed phase


MS ID:MS002650
Analysis ID:AN002857
Instrument Name:Thermo Exactive Plus Orbitrap
Instrument Type:Orbitrap
MS Comments:see attached
MS ID:MS002651
Analysis ID:AN002858
Instrument Name:Thermo Exactive Plus Orbitrap
Instrument Type:Orbitrap
MS Comments:see attached