Summary of Study ST002141
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001356. The data can be accessed directly via it's Project DOI: 10.21228/M8FD6B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002141 |
| Study Title | Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study |
| Study Summary | A study to determine whether long-term NR supplementation could improve mitochondrial biogenesis in humans |
| Institute | University of Helsinki |
| Last Name | Muniandy |
| First Name | Maheswary |
| Address | P.O. Box 4 (Yliopistonkatu 3), Helsinki |
| maheswary.muniandy@helsinki.fi | |
| Phone | +3582941911 |
| Submit Date | 2022-04-12 |
| Num Groups | 4 |
| Total Subjects | 16 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-12-31 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001356 |
| Project DOI: | doi: 10.21228/M8FD6B |
| Project Title: | Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study |
| Project Type: | Human intervention |
| Project Summary: | Intervention studies to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans |
| Institute: | University of Helsinki |
| Last Name: | Muniandy |
| First Name: | Maheswary |
| Address: | Yliopistonkatu 4, 00100 Helsinki, Helsinki, Helsinki, 00100, Finland |
| Email: | maheswary.muniandy@helsinki.fi |
| Phone: | +3582941911 |
Subject:
| Subject ID: | SU002226 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Gender: | Male and female |
| Species Group: | Mammals |
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Data_Type | Twin_type | visit |
|---|---|---|---|---|
| SA205474 | 1000V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205475 | 1019V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205476 | 1008V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205477 | 1022V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205478 | 1031V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205479 | 1043V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205480 | 1045V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205481 | 1018V2-HILIC_neg | HILIC_neg | concordant | Post |
| SA205482 | 1019V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205483 | 1045V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205484 | 1022V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205485 | 1008V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205486 | 1043V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205487 | 1031V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205488 | 1000V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205489 | 1018V1-HILIC_neg | HILIC_neg | concordant | Pre |
| SA205490 | 1003V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205491 | 1046V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205492 | 1039V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205493 | 1012V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205494 | 1014V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205495 | 1047V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205496 | 1026V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205497 | 1036V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205498 | 1011V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205499 | 1035V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205500 | 1034V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205501 | 1024V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205502 | 1016V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205503 | 1050V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205504 | 1041V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205505 | 1037V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205506 | 1005V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205507 | 1007V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205508 | 1027V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205509 | 1028V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205510 | 1038V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205511 | 1042V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205512 | 1013V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205513 | 1049V2-HILIC_neg | HILIC_neg | discordant | Post |
| SA205514 | 1046V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205515 | 1012V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205516 | 1014V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205517 | 1027V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205518 | 1039V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205519 | 1041V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205520 | 1049V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205521 | 1038V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205522 | 1042V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205523 | 1037V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205524 | 1013V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205525 | 1047V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205526 | 1003V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205527 | 1036V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205528 | 1011V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205529 | 1035V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205530 | 1028V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205531 | 1024V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205532 | 1016V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205533 | 1034V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205534 | 1050V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205535 | 1007V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205536 | 1005V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205537 | 1026V1-HILIC_neg | HILIC_neg | discordant | Pre |
| SA205538 | 1022V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205539 | 1008V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205540 | 1000V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205541 | 1043V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205542 | 1031V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205543 | 1045V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205544 | 1018V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205545 | 1019V2-HILIC_pos | HILIC_pos | concordant | Post |
| SA205546 | 1043V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205547 | 1000V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205548 | 1045V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205549 | 1022V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205550 | 1031V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205551 | 1018V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205552 | 1019V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205553 | 1008V1-HILIC_pos | HILIC_pos | concordant | Pre |
| SA205554 | 1014V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205555 | 1034V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205556 | 1016V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205557 | 1046V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205558 | 1012V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205559 | 1024V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205560 | 1047V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205561 | 1039V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205562 | 1003V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205563 | 1035V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205564 | 1037V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205565 | 1028V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205566 | 1005V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205567 | 1041V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205568 | 1027V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205569 | 1036V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205570 | 1011V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205571 | 1050V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205572 | 1007V2-HILIC_pos | HILIC_pos | discordant | Post |
| SA205573 | 1026V2-HILIC_pos | HILIC_pos | discordant | Post |
Collection:
| Collection ID: | CO002219 |
| Collection Summary: | Human blood samples before and after treatment with NR |
| Sample Type: | Blood (plasma) |
Treatment:
| Treatment ID: | TR002238 |
| Treatment Summary: | NR treatment: Baseline and after 5 months |
Sample Preparation:
| Sampleprep ID: | SP002232 |
| Sampleprep Summary: | Routine blood tests were performed for all study participants. Blood samples were collected after overnight fasting, and whole blood, separated plasma and serum samples were frozen at -80C. |
| Processing Storage Conditions: | -80℃ |
| Extract Storage: | -80℃ |
Chromatography:
| Chromatography ID: | CH002589 |
| Instrument Name: | Thermo Vanquish |
| Column Name: | Agilent Zorbax Eclipse Plus C18 (100 x 2.1mm, 1.8 um) |
| Chromatography Type: | Reversed phase |
| Chromatography ID: | CH002590 |
| Instrument Name: | Agilent 1290 |
| Column Name: | Waters Acquity BEH Amide (150 x 2.1mm,1.7um) |
| Chromatography Type: | HILIC |
Analysis:
| Analysis ID: | AN003503 |
| Analysis Type: | MS |
| Chromatography ID: | CH002589 |
| Has Mz: | 1 |
| Has Rt: | 1 |
| Rt Units: | Seconds |
| Results File: | ST002141_AN003503_Results.txt |
| Units: | mz |
| Analysis ID: | AN003504 |
| Analysis Type: | MS |
| Chromatography ID: | CH002589 |
| Has Mz: | 1 |
| Has Rt: | 1 |
| Rt Units: | Seconds |
| Results File: | ST002141_AN003504_Results.txt |
| Units: | mz |
| Analysis ID: | AN003505 |
| Analysis Type: | MS |
| Chromatography ID: | CH002590 |
| Has Mz: | 1 |
| Has Rt: | 1 |
| Rt Units: | Seconds |
| Results File: | ST002141_AN003505_Results.txt |
| Units: | mz |
| Analysis ID: | AN003506 |
| Analysis Type: | MS |
| Chromatography ID: | CH002590 |
| Has Mz: | 1 |
| Has Rt: | 1 |
| Rt Units: | Seconds |
| Results File: | ST002141_AN003506_Results.txt |
| Units: | mz |