Summary of Study ST003368

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002091. The data can be accessed directly via it's Project DOI: 10.21228/M8B83W This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003368
Study TitleNon-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning
Study SummaryMoyamoya disease (MMD) is a progressive cerebrovascular condition that elevates the risk of intracranial ischemia and hemorrhage. Timely diagnosis and intervention can considerably lower the chances of new stroke occurrences in MMD patients. However, existing diagnostic techniques are both invasive and costly, with few reports on non-invasive diagnosis using MMD biomarkers. To tackle this challenge, we conducted non-targeted metabolomics analysis using LDI-MS on serum from 288 samples (validation cohort: MMD/HC: 115/115; discovery cohort: MMD/HC: 29/29) to identify patients with MMD. We then created a diagnostic model leveraging deep learning algorithms, which demonstrated remarkable accuracy in distinguishing the MMD group from the HC group (AUC = 0.977, 95% CI of 0.945 to 1.000). This method represents a promising new approach for MMD diagnosis. Additionally, our findings may have wider implications for the diagnosis of other neurological disorders.
Institute
Shanghai Jiao Tong University affiliated Renji Hospital
Last NameXu
First NameYudian
AddressShanghai, 200127, P. R. China, Shanghai, Shanghai, 200127, China
Emailxuyd9r@sjtu.edu.cn
Phone19370718762
Submit Date2024-07-14
Analysis Type DetailMALDI-MS
Release Date2024-09-16
Release Version1
Yudian Xu Yudian Xu
https://dx.doi.org/10.21228/M8B83W
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR002091
Project DOI:doi: 10.21228/M8B83W
Project Title:Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning
Project Summary:Moyamoya disease (MMD) is a progressive cerebrovascular disorder that raises the risk of intracranial ischemia and hemorrhage. For a non-invasive diagnostic approach to MMD, we used nanoparticle-enhanced laser desorption/ionization mass spectrometry (LDI-MS) to analyze serum metabolic fingerprints (SMFs) in a validation cohort (MMD: 115/HC: 115) and a discovery cohort (MMD: 29/HC: 29).
Institute:Shanghai Jiao Tong University affiliated Renji Hospital
Last Name:Xu
First Name:Yudian
Address:Shanghai, 200127, P. R. China, Shanghai, Shanghai, 200127, China
Email:xuyd9r@sjtu.edu.cn
Phone:19370718762

Subject:

Subject ID:SU003489
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male and female
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA366602Discovery_101HC
SA366603Discovery_95HC
SA366604Discovery_96HC
SA366605Discovery_97HC
SA366606Discovery_98HC
SA366607Discovery_99HC
SA366608Discovery_100HC
SA366609Discovery_102HC
SA366610Discovery_93HC
SA366611Discovery_103HC
SA366612Discovery_104HC
SA366613Discovery_105HC
SA366614Discovery_106HC
SA366615Discovery_107HC
SA366616Discovery_108HC
SA366617Discovery_94HC
SA366618Discovery_92HC
SA366619Discovery_110HC
SA366620Discovery_83HC
SA366621Discovery_77HC
SA366622Discovery_78HC
SA366623Discovery_79HC
SA366624Discovery_80HC
SA366625Discovery_81HC
SA366626Discovery_82HC
SA366627Discovery_84HC
SA366628Discovery_91HC
SA366629Discovery_85HC
SA366630Discovery_86HC
SA366631Discovery_87HC
SA366632Discovery_88HC
SA366633Discovery_89HC
SA366634Discovery_90HC
SA366635Discovery_109HC
SA366636Discovery_111HC
SA366637Discovery_75HC
SA366638Validation_22HC
SA366639Validation_16HC
SA366640Validation_17HC
SA366641Validation_18HC
SA366642Validation_19HC
SA366643Validation_20HC
SA366644Validation_21HC
SA366645Validation_23HC
SA366646Validation_14HC
SA366647Validation_24HC
SA366648Validation_25HC
SA366649Validation_26HC
SA366650Validation_27HC
SA366651Validation_28HC
SA366652Validation_29HC
SA366653Validation_15HC
SA366654Validation_13HC
SA366655Discovery_112HC
SA366656Validation_3HC
SA366657Discovery_113HC
SA366658Discovery_114HC
SA366659Discovery_115HC
SA366660Discovery_2HC
SA366661Validation_1HC
SA366662Validation_2HC
SA366663Validation_4HC
SA366664Validation_12HC
SA366665Validation_5HC
SA366666Validation_6HC
SA366667Validation_7HC
SA366668Validation_8HC
SA366669Validation_9HC
SA366670Validation_10HC
SA366671Validation_11HC
SA366672Discovery_76HC
SA366673Discovery_1HC
SA366674Discovery_74HC
SA366675Discovery_29HC
SA366676Discovery_7HC
SA366677Discovery_6HC
SA366678Discovery_5HC
SA366679Discovery_4HC
SA366680Discovery_3HC
SA366681Discovery_32HC
SA366682Discovery_30HC
SA366683Discovery_9HC
SA366684Discovery_31HC
SA366685Discovery_73HC
SA366686Discovery_28HC
SA366687Discovery_33HC
SA366688Discovery_34HC
SA366689Discovery_35HC
SA366690Discovery_8HC
SA366691Discovery_10HC
SA366692Discovery_37HC
SA366693Discovery_20HC
SA366694Discovery_26HC
SA366695Discovery_25HC
SA366696Discovery_24HC
SA366697Discovery_23HC
SA366698Discovery_22HC
SA366699Discovery_21HC
SA366700Discovery_19HC
SA366701Discovery_11HC
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Collection:

Collection ID:CO003482
Collection Summary:All human peripheral venous blood samples were obtained following the protocols approved by the Institutional Review Board at Huashan Hospital. Blood samples were obtained at the same time as regular blood tests after overnight fasting and then centrifuged for 10 minutes (1500g, 4℃). Serum samples were aliquoted in sterile centrifuge tubes and stored at -80℃ storage freezer.
Sample Type:Blood (serum)

Treatment:

Treatment ID:TR003498
Treatment Summary:none

Sample Preparation:

Sampleprep ID:SP003496
Sampleprep Summary:At the beginning, all original serum samples were diluted 10 times by 10ul to obtain diluted serum, and both the original serum and the diluted serum were placed at -80℃ for later use. In LDI MS experiments, 1 μL of analyte solution (prepared standard small metabolites or diluted samples) was first spotted on the polished steel plate and dried, followed by depositing 1 μL of nanoparticle suspension or organic matrix solution and dried in air at room temperature.

Chromatography:

Chromatography ID:CH004196
Instrument Name:none
Column Name:none
Column Temperature:none
Flow Gradient:none
Flow Rate:none
Solvent A:None
Solvent B:none
Chromatography Type:None (Direct infusion)

Analysis:

Analysis ID:AN005520
Analysis Type:MS
Chromatography ID:CH004196
Has Mz:1
Rt Units:No RT data
Results File:ST003368_AN005520_Results.txt
Units:Relative intensity
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