Summary of Study ST003674

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002279. The data can be accessed directly via it's Project DOI: 10.21228/M81Z5R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST003674
Study TitleMetabolomic and lipoproteomic differences and similarities among different types of pneumonia
Study TypeNMR-based metabolomics
Study SummaryAn 1H NMR analysis of the plasma of patients with non-COVID-19 interstitial (24 individuals) or lobar (21 individuals) pneumonia, all matched by age, gender and disease severity has been performed to compare the metabolomic and lipoproteomics profiles of different types of pneumonia. The analysis is based on 24 metabolites and 114 lipoprotein parameters. Several common traits are observed between the two groups, with the most dysregulated molecules in the lobar group (same trends of changes but higher fold changes); some peculiar features characteristic of each group could be also identified.
Institute
University of Florence
DepartmentDepartment of Chemistry
LaboratoryMetabolomics
Last NameGhini
First NameVeronica
Addressvia Luigi Sacconi 6
Emailghini@cerm.unifi.it
Phone+390554574266
Submit Date2025-01-16
Num Groups2
Total Subjects45
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2025-02-11
Release Version1
Veronica Ghini Veronica Ghini
https://dx.doi.org/10.21228/M81Z5R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR002279
Project DOI:doi: 10.21228/M81Z5R
Project Title:Metabolomic and lipoproteomic differences and similarities between COVID-19 and other types of pneumonia
Project Summary:Comparative 1H NMR analyses of the plasma of patients with non-COVID-19 interstitial (24 individuals) or lobar (21 individuals) pneumonia, all matched by age, gender and disease severity. The analysis is based on 24 metabolites and 114 lipoprotein parameters.
Institute:University of Florence
Department:Department of Chemistry
Laboratory:Metabolomics
Last Name:Ghini
First Name:Veronica
Address:via Luigi Sacconi 6
Email:ghini@cerm.unifi.it
Phone:+390554574266

Subject:

Subject ID:SU003806
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male and female

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sex Pneumonia
SA401757P_798F INT
SA401758P_796F INT
SA401759P_802F INT
SA401760P_810F INT
SA401761P_790F INT
SA401762P_811F INT
SA401763P_785F INT
SA401764P_814F INT
SA401765P_816F INT
SA401766P_818F INT
SA401767P_774F INT
SA401768P_770F INT
SA401769P_829F INT
SA401770P_824F LOB
SA401771P_776F LOB
SA401772P_782F LOB
SA401773P_787F LOB
SA401774P_769F LOB
SA401775P_766F LOB
SA401776P_765F LOB
SA401777P_764F LOB
SA401778P_797F LOB
SA401779P_821M INT
SA401780P_815M INT
SA401781P_827M INT
SA401782P_803M INT
SA401783P_762M INT
SA401784P_780M INT
SA401785P_795M INT
SA401786P_792M INT
SA401787P_772M INT
SA401788P_777M INT
SA401789P_778M INT
SA401790P_779M LOB
SA401791P_833M LOB
SA401792P_767M LOB
SA401793P_799M LOB
SA401794P_817M LOB
SA401795P_800M LOB
SA401796P_783M LOB
SA401797P_784M LOB
SA401798P_789M LOB
SA401799P_763M LOB
SA401800P_801M LOB
SA401801P_793M LOB
Showing results 1 to 45 of 45

Collection:

Collection ID:CO003799
Collection Summary:The patients included in the study were hospitalized in Florence, Italy. Patients with lobar and interstitial pneumonia, according to radiographic reports and negative for COVID-19 swabs, were enrolled in the study. Blood samples were collected at the moment of admission to the hospital, before the start of any therapy or other medical interventions. The analyses were done on EDTA-plasma samples. All the samples were collected, processed and stored following the ISO standards (ISO 23118:2021), designed for high quality biological samples for metabolomic analysis.
Sample Type:Blood (plasma)
Storage Conditions:-80℃
Additives:EDTA

Treatment:

Treatment ID:TR003815
Treatment Summary:Not applicable

Sample Preparation:

Sampleprep ID:SP003813
Sampleprep Summary:Frozen EDTA-plasma samples were thawed at room temperature and shaken before use. A total of 350 μL of sodium phosphate buffer (70 mM Na2HPO4; 20% (v/v) 2H2O; 6.1 mM NaN3, 4.6 mM sodium trimethylsilyl [2,2,3,3−2H4] propionate (TMSP), pH 7.4) was added to 350 μL of each serum sample; the mixture was homogenized by vortexing for 30 s. A total of 600 μL of each mixture was transferred into a 5.00 mm NMR tube (Bruker BioSpin) for the analysis.

Analysis:

Analysis ID:AN006035
Analysis Type:NMR
Num Factors:4
Num Metabolites:139
Units:AU

NMR:

NMR ID:NM000303
Analysis ID:AN006035
Instrument Name:Bruker 600 MHz
Instrument Type:FT-NMR
NMR Experiment Type:1D-1H
Spectrometer Frequency:600 MHz
NMR Probe:5-mm PATXI 1H-13C-15N and 2H-decoupling probe
NMR Solvent:H2O
NMR Tube Size:5 mm
Pulse Sequence:noesygp1D; cpmg1D; diffusion-edited
Water Suppression:water peak suppression-presaturation
Receiver Gain:90.5
Temperature:37
Number Of Scans:32
Dummy Scans:4
Acquisition Time:2.7s
Relaxation Delay:4s
Spectral Width:18,028 Hz
Num Data Points Acquired:98000
Line Broadening:0.3
Baseline Correction Method:automatic
Chemical Shift Ref Std:doublet at 5.24 ppm
  logo