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ST000054 Metabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
ABCA transporters in lipid homeostasis (1)
REACT_111158
ABH2 mediated Reversal of Alkylation Damage (1)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (1)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (1)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (7)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (8)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Biotin transport and metabolism (1)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Branched-chain amino acid catabolism (4)
REACT_197
Carnitine synthesis (1)
REACT_2125
Cell surface interactions at the vascular wall (1)
REACT_12051
Cholesterol biosynthesis (1)
REACT_9405
Chylomicron-mediated lipid transport (1)
REACT_6841
Circadian Clock (2)
REACT_24941
Citric acid cycle (TCA cycle) (3)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (2)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2)
REACT_18319
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (1)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (8)
REACT_15306
Degradation of cysteine and homocysteine (1)
REACT_115654
Degradation of GABA (3)
REACT_23964
Digestion of dietary lipid (3)
REACT_9518
Endogenous sterols (1)
REACT_13812
Endosomal/Vacuolar pathway (8)
REACT_111168
eNOS activation (1)
REACT_12477
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (8)
REACT_111178
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4)
REACT_19193
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
Free fatty acid receptors (6)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (3)
REACT_19231
G alpha (q) signalling events (6)
REACT_18283
Gluconeogenesis (5)
REACT_1520
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione synthesis and recycling (9)
REACT_6960
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (1)
REACT_16925
HDL-mediated lipid transport (1)
REACT_13621
HDMs demethylate histones (1)
REACT_228178
Hedgehog ligand biogenesis (1)
REACT_228111
Histidine catabolism (1)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2)
REACT_494
HS-GAG degradation (1)
REACT_120752
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
LDL-mediated lipid transport (1)
REACT_6934
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (3)
REACT_1298
Metabolism of folate and pterines (2)
REACT_11167
Mitochondrial tRNA aminoacylation (8)
REACT_15302
Na+/Cl- dependent neurotransmitter transporters (6)
REACT_20506
NADPH regeneration (1)
REACT_16904
Nicotinate metabolism (1)
REACT_11088
Organic anion transport (1)
REACT_22310
Organic anion transporters (2)
REACT_19372
Orphan transporters (3)
REACT_267716
Oxidative Stress Induced Senescence (1)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_120916
Passive transport by Aquaporins (2)
REACT_23826
Phenylalanine and tyrosine catabolism (2)
REACT_1786
Plasmalogen biosynthesis (1)
REACT_1407
Platelet sensitization by LDL (1)
REACT_23879
PPARA activates gene expression (2)
REACT_116145
Pregnenolone biosynthesis (1)
REACT_11038
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (8)
REACT_19328
Purine ribonucleoside monophosphate biosynthesis (2)
REACT_1776
Pyrimidine biosynthesis (2)
REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (4)
REACT_24968
REV-ERBA represses gene expression (2)
REACT_118789
RORA activates circadian gene expression (2)
REACT_118659
Scavenging by Class A Receptors (1)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Scavenging by Class H Receptors (1)
REACT_164002
Scavenging of heme from plasma (1)
REACT_160163
Serine biosynthesis (3)
REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (1)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1)
REACT_21330
Synthesis of bile acids and bile salts (1)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PG (1)
REACT_121280
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (4)
REACT_23824
TET1,2,3 and TDG demethylate DNA (1)
REACT_200682
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Trafficking of dietary sterols (1)
REACT_13781
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Transport of fatty acids (6)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2)
REACT_19397
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (2)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (3)
REACT_847
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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