ST000239 Sexual antagonism in exuded non-volatile metabolites in C. purpureus
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (3) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (8) REACT_238
Amino acid transport across the plasma membrane (15) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (14) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (15) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (2) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (3) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
cGMP effects (1) REACT_23767
Chondroitin sulfate biosynthesis (1) REACT_120989
Citric acid cycle (TCA cycle) (1) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (14) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (15) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (3) REACT_23964
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (14) REACT_111168
eNOS activation (1) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (14) REACT_111178
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (3) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (6) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (14) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (2) REACT_169208
Glycolysis (3) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (2) REACT_16925
Heme degradation (1) REACT_22297
Histidine catabolism (3) REACT_1249
HS-GAG biosynthesis (2) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (1) REACT_1298
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (3) REACT_75881
Methylation (2) REACT_6946
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (15) REACT_15302
Molybdenum cofactor biosynthesis (4) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (13) REACT_20506
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
P2Y receptors (1) REACT_18289
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Plasmalogen biosynthesis (1) REACT_1407
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in Golgi (1) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (14) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (6) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of ornithine decarboxylase (ODC) (1) REACT_13565
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (3) REACT_70
Removal of the Flap Intermediate from the C-strand (3) REACT_7999
Respiratory electron transport (1) REACT_22393
Reuptake of GABA (1) REACT_23910
RMTs methylate histone arginines (1) REACT_228108
Scavenging by Class A Receptors (1) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (3) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (2) REACT_160189
Sulfur amino acid metabolism (3) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (6) REACT_21330
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (2) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (1) REACT_15292
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (3) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (6) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
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