ST000335 Metabolomics of bovine uterine fluid at the onset of conceptus elongation
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (5) REACT_121117
Acetylation (2) REACT_6732
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (2) REACT_14800
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (20) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18) REACT_75842
Arachidonate production from DAG (2) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (6) REACT_197
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (4) REACT_15551
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of phenylacetate with glutamine (3) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (4) REACT_6913
Cytosolic tRNA aminoacylation (18) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (3) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (4) REACT_9518
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (18) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (18) REACT_111178
Fatty acids (3) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FMO oxidises nucleophiles (2) REACT_13653
Free fatty acid receptors (4) REACT_21268
Fructose catabolism (1) REACT_1571
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (9) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (6) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (20) REACT_6960
Glycolysis (2) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (1) REACT_9465
Histamine receptors (1) REACT_16903
Histidine catabolism (4) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG degradation (1) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Insulin effects increased synthesis of Xylulose-5-Phosphate (1) REACT_939
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (2) REACT_14805
Iron uptake and transport (1) REACT_25060
Ligand-gated ion channel transport (2) REACT_25387
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (1) REACT_6946
Miscellaneous substrates (2) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (18) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
MyD88 dependent cascade initiated on endosome (1) REACT_25222
Na+/Cl- dependent neurotransmitter transporters (20) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
Organic anion transport (3) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (5) REACT_22357
Orphan transporters (6) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
PAOs oxidise polyamines to amines (2) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (2) REACT_1407
PPARA activates gene expression (2) REACT_116145
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Prostanoid ligand receptors (1) REACT_18425
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (18) REACT_19328
Purine catabolism (4) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (2) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (5) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (4) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (2) REACT_118659
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (3) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (4) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (4) REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (5) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (3) REACT_15292
Toll Like Receptor 7/8 (TLR7/8) Cascade (1) REACT_9020
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (1) REACT_25024
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling (1) REACT_25120
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (4) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (4) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of organic anions (3) REACT_23988
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (8) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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