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ST000340 Metformin effects on liver and kidney tissueList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abnormal metabolism in phenylketonuria (1)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Amino acid synthesis and interconversion (transamination) (1)
REACT_238
Amino acid transport across the plasma membrane (6)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (6)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (6)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (1)
REACT_197
Carnitine synthesis (2)
REACT_2125
Class C/3 (Metabotropic glutamate/pheromone receptors) (3)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (6)
REACT_111056
Cytosolic tRNA aminoacylation (6)
REACT_15306
Degradation of GABA (1)
REACT_23964
Endosomal/Vacuolar pathway (6)
REACT_111168
eNOS activation (1)
REACT_12477
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (6)
REACT_111178
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (1)
REACT_19231
G alpha (q) signalling events (3)
REACT_18283
Gluconeogenesis (1)
REACT_1520
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione synthesis and recycling (6)
REACT_6960
Histidine catabolism (1)
REACT_1249
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Lysine catabolism (2)
REACT_1298
Metabolism of folate and pterines (1)
REACT_11167
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Mitochondrial tRNA aminoacylation (6)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (5)
REACT_20506
Nicotinate metabolism (1)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
Organic anion transporters (1)
REACT_19372
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (2)
REACT_1786
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (1)
REACT_1002
Proton/oligonucleotide cotransporters (6)
REACT_19328
Purine catabolism (1)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1)
REACT_1776
Purine salvage (1)
REACT_1923
Pyrimidine biosynthesis (1)
REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Serine biosynthesis (1)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sulfur amino acid metabolism (2)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1)
REACT_21330
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1)
REACT_1206
Tryptophan catabolism (3)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (2)
REACT_847
VEGFR2 mediated vascular permeability (1)
REACT_228016
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