ST000340 Metformin effects on liver and kidney tissue
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abnormal metabolism in phenylketonuria (1) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Amino acid synthesis and interconversion (transamination) (1) REACT_238
Amino acid transport across the plasma membrane (6) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (6) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (6) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (1) REACT_197
Carnitine synthesis (2) REACT_2125
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (6) REACT_111056
Cytosolic tRNA aminoacylation (6) REACT_15306
Degradation of GABA (1) REACT_23964
Endosomal/Vacuolar pathway (6) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (6) REACT_111178
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (3) REACT_18283
Gluconeogenesis (1) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (6) REACT_6960
Histidine catabolism (1) REACT_1249
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Mitochondrial tRNA aminoacylation (6) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (5) REACT_20506
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transporters (1) REACT_19372
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Proton/oligonucleotide cotransporters (6) REACT_19328
Purine catabolism (1) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1) REACT_1776
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Tryptophan catabolism (3) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (2) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
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