ST000475 Metabolomic testing of a putative MDH inhibitor (global)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (2) REACT_228214
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (13) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (11) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (11) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Branched-chain amino acid catabolism (3) REACT_197
Catecholamine biosynthesis (1) REACT_15551
Citric acid cycle (TCA cycle) (2) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Conjugation of phenylacetate with glutamine (1) REACT_6800
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (11) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (11) REACT_15306
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Endosomal/Vacuolar pathway (11) REACT_111168
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (11) REACT_111178
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (1) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (13) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (2) REACT_1383
Histidine catabolism (1) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (11) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (12) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinate metabolism (2) REACT_11088
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (1) REACT_267716
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (11) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (6) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Reuptake of GABA (2) REACT_23910
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (5) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (5) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PA (2) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Termination of O-glycan biosynthesis (1) REACT_115835
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (1) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (7) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Tryptophan catabolism (3) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
Vitamin C (ascorbate) metabolism (1) REACT_11202
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