ST000551 Investigating large scale metabolomics in mice tissue lacking insulin receptors and IGF-1 receptors
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (1) REACT_121388
Acetylation (1) REACT_6732
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (1) REACT_228214
Amino acid synthesis and interconversion (transamination) (1) REACT_238
Amino acid transport across the plasma membrane (6) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (5) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (5) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Branched-chain amino acid catabolism (3) REACT_197
Ca2+ pathway (1) REACT_172761
cGMP effects (1) REACT_23767
Class C/3 (Metabotropic glutamate/pheromone receptors) (1) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (5) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (5) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary lipid (1) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (5) REACT_111168
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (5) REACT_111178
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (1) REACT_18283
Gluconeogenesis (1) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (5) REACT_6960
Glycogen synthesis (1) REACT_169208
Histidine catabolism (2) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
Keratan sulfate biosynthesis (1) REACT_121120
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Methylation (1) REACT_6946
Mitochondrial tRNA aminoacylation (5) REACT_15302
mRNA Capping (1) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (5) REACT_20506
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (2) REACT_11088
Organic anion transporters (1) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Phenylalanine and tyrosine catabolism (1) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Proton/oligonucleotide cotransporters (5) REACT_19328
Purine catabolism (4) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Scavenging by Class A Receptors (2) REACT_163699
Serine biosynthesis (1) REACT_115789
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (3) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (4) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (1) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (1) REACT_847
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