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ST000577 Effects of the Kinase Inhibitor Sorafenib on Liver Metabolism In Vivo using Non-targeted Metabolomics Analysis tissue).List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (4)
REACT_121117
Activation of gene expression by SREBF (SREBP) (1)
REACT_147904
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Alpha-oxidation of phytanate (2)
REACT_17003
Amino acid synthesis and interconversion (transamination) (5)
REACT_238
Amino acid transport across the plasma membrane (9)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1)
REACT_111118
Branched-chain amino acid catabolism (2)
REACT_197
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Cholesterol biosynthesis (1)
REACT_9405
Circadian Clock (1)
REACT_24941
Citric acid cycle (TCA cycle) (3)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (3)
REACT_14828
Cleavage of the damaged pyrimidine (1)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Collagen biosynthesis and modifying enzymes (2)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
COX reactions (1)
REACT_1396
Creatine metabolism (1)
REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (9)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (9)
REACT_15306
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (2)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Endosomal/Vacuolar pathway (9)
REACT_111168
ER-Phagosome pathway (9)
REACT_111178
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Free fatty acid receptors (2)
REACT_21268
G alpha (i) signalling events (4)
REACT_19231
G alpha (q) signalling events (1)
REACT_18283
Gluconeogenesis (4)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (10)
REACT_6960
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
HDMs demethylate histones (2)
REACT_228178
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (2)
REACT_120785
Hydroxycarboxylic acid-binding receptors (2)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inositol transporters (1)
REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
Interconversion of polyamines (1)
REACT_14805
Lysine catabolism (1)
REACT_1298
Metabolism of folate and pterines (1)
REACT_11167
Metabolism of polyamines (1)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mitochondrial tRNA aminoacylation (9)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (9)
REACT_20506
NADPH regeneration (1)
REACT_16904
Organic anion transport (2)
REACT_22310
Organic anion transporters (2)
REACT_19372
Organic cation transport (2)
REACT_22357
Orphan transporters (1)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
PAOs oxidise polyamines to amines (1)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (5)
REACT_1786
phospho-PLA2 pathway (1)
REACT_15466
Plasmalogen biosynthesis (1)
REACT_1407
PPARA activates gene expression (1)
REACT_116145
Proline catabolism (1)
REACT_1002
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (9)
REACT_19328
Purine catabolism (1)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1)
REACT_1776
Pyrimidine biosynthesis (1)
REACT_21376
Pyrimidine catabolism (2)
REACT_1023
Pyrimidine salvage reactions (1)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Recycling of bile acids and salts (1)
REACT_11042
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
REV-ERBA represses gene expression (1)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (1)
REACT_118659
Serine biosynthesis (3)
REACT_115789
Sialic acid metabolism (1)
REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (2)
REACT_115810
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (1)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (2)
REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PA (2)
REACT_120906
Synthesis of PE (2)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1)
REACT_23824
TET1,2,3 and TDG demethylate DNA (2)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (1)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (1)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (1)
REACT_27161
Transport of fatty acids (3)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1)
REACT_1206
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (3)
REACT_916
Urea cycle (2)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
Vitamin C (ascorbate) metabolism (1)
REACT_11202
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1)
REACT_118713
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