ST000916 Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 2:Plasma
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABCA transporters in lipid homeostasis (1) REACT_111158
Activation of gene expression by SREBF (SREBP) (4) REACT_147904
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4) REACT_111118
Cell surface interactions at the vascular wall (1) REACT_12051
Cholesterol biosynthesis (5) REACT_9405
Chylomicron-mediated lipid transport (1) REACT_6841
Circadian Clock (4) REACT_24941
COX reactions (1) REACT_1396
Cytosolic sulfonation of small molecules (1) REACT_6913
Digestion of dietary lipid (2) REACT_9518
Endogenous sterols (7) REACT_13812
eNOS activation (1) REACT_12477
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (9) REACT_21268
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Glycosphingolipid metabolism (1) REACT_116105
HDL-mediated lipid transport (1) REACT_13621
Hedgehog ligand biogenesis (1) REACT_228111
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
LDL-mediated lipid transport (1) REACT_6934
Leukotriene receptors (1) REACT_18302
Linoleic acid (LA) metabolism (1) REACT_121100
Lysosphingolipid and LPA receptors (1) REACT_18365
Miscellaneous substrates (1) REACT_13425
Orphan transporters (9) REACT_267716
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (1) REACT_1407
Platelet sensitization by LDL (1) REACT_23879
PPARA activates gene expression (4) REACT_116145
Pregnenolone biosynthesis (1) REACT_11038
Prostanoid ligand receptors (1) REACT_18425
Pyrimidine biosynthesis (1) REACT_21376
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4) REACT_19241
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
REV-ERBA represses gene expression (4) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (4) REACT_118659
Scavenging by Class A Receptors (2) REACT_163699
Scavenging by Class B Receptors (2) REACT_163679
Scavenging by Class F Receptors (2) REACT_163813
Scavenging by Class H Receptors (1) REACT_164002
Scavenging of heme from plasma (1) REACT_160163
Sphingolipid de novo biosynthesis (4) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (2) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (3) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (3) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (5) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (2) REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (7) REACT_150149
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (9) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Trafficking of dietary sterols (1) REACT_13781
Transcriptional activation of mitochondrial biogenesis (4) REACT_200608
Transcriptional regulation of white adipocyte differentiation (4) REACT_27161
Transport of fatty acids (5) REACT_23892
Transport of organic anions (1) REACT_23988
VEGFR2 mediated cell proliferation (2) REACT_228024
Vitamin D (calciferol) metabolism (2) REACT_13523
Vitamins (1) REACT_13450
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4) REACT_118713
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