ST001037 High Resolution GC-MS and FID Metabolomics of Human Serum
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2) REACT_850
Abacavir metabolism (2) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (12) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (11) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (12) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biotin transport and metabolism (3) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (3) REACT_197
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Cell redox homeostasis (1) REACT_121394
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (2) REACT_24941
Citric acid cycle (TCA cycle) (2) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Class II GLUTs (1) REACT_19281
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (11) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (12) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary lipid (3) REACT_9518
DNA methylation (2) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (11) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
ER-Phagosome pathway (11) REACT_111178
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
Free fatty acid receptors (2) REACT_21268
Galactose catabolism (1) REACT_532
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (3) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (4) REACT_1520
Glutathione synthesis and recycling (12) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycolysis (3) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Glyoxylate metabolism (1) REACT_16925
Histidine catabolism (2) REACT_1249
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inositol transporters (1) REACT_19188
Interconversion of polyamines (1) REACT_14805
ISG15 antiviral mechanism (1) REACT_115831
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (2) REACT_1298
Meiotic recombination (2) REACT_27271
Metabolism of Angiotensinogen to Angiotensins (2) REACT_147707
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (2) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methylation (3) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (12) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (12) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Organic anion transport (3) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (1) REACT_23826
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (3) REACT_116145
PRC2 methylates histones and DNA (2) REACT_200808
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (11) REACT_19328
Purine catabolism (3) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (3) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (2) REACT_2071
Recycling of bile acids and salts (4) REACT_11042
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Respiratory electron transport (2) REACT_22393
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
REV-ERBA represses gene expression (2) REACT_118789
RMTs methylate histone arginines (2) REACT_228108
RORA activates circadian gene expression (2) REACT_118659
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (2) REACT_160189
Sulfur amino acid metabolism (3) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (2) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The fatty acid cycling model (1) REACT_6258
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (3) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (4) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Transport of organic anions (2) REACT_23988
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (4) REACT_916
Ubiquinol biosynthesis (2) REACT_160111
Urea cycle (3) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
  logo