ST001056 Evaluation of the short-term effects of the allelochemical umbelliferone on Triticum durum L. metabolism through GC-MS based untargeted metabolomics
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (1) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (8) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (8) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (3) REACT_197
Carnitine synthesis (1) REACT_2125
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cleavage of the damaged pyrimidine (1) REACT_2156
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of phenylacetate with glutamine (1) REACT_6800
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic tRNA aminoacylation (8) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (3) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (2) REACT_9518
Endosomal/Vacuolar pathway (8) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (8) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
Free fatty acid receptors (3) REACT_21268
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (5) REACT_19231
G alpha (q) signalling events (4) REACT_18283
Gluconeogenesis (4) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (9) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (1) REACT_228178
Histidine catabolism (1) REACT_1249
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of polyamines (1) REACT_14805
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (1) REACT_14820
Methylation (1) REACT_6946
Mitochondrial tRNA aminoacylation (8) REACT_15302
Na+/Cl- dependent neurotransmitter transporters (7) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinate metabolism (2) REACT_11088
Organic anion transport (1) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (3) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
PAOs oxidise polyamines to amines (1) REACT_505
Phenylalanine and tyrosine catabolism (1) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (1) REACT_116145
Presynaptic function of Kainate receptors (1) REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (8) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (1) REACT_11042
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
Role of phospholipids in phagocytosis (1) REACT_160158
RORA activates circadian gene expression (1) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Serine biosynthesis (2) REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PS (3) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2) REACT_23824
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (2) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (1) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (2) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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