ST001119 Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2) REACT_850
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (1) REACT_163932
Acyl chain remodeling of CL (1) REACT_121006
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Acyl chain remodelling of PC (1) REACT_120829
Acyl chain remodelling of PE (1) REACT_121369
Acyl chain remodelling of PG (1) REACT_121324
Acyl chain remodelling of PI (1) REACT_120722
Acyl chain remodelling of PS (1) REACT_121384
Aflatoxin activation and detoxification (4) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (4) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (23) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (20) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Attenuation phase (1) REACT_200624
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (3) REACT_11153
Branched-chain amino acid catabolism (7) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (4) REACT_2125
Catecholamine biosynthesis (3) REACT_15551
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (1) REACT_9405
Citric acid cycle (TCA cycle) (6) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (3) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of phenylacetate with glutamine (4) REACT_6800
Conjugation of salicylate with glycine (3) REACT_6812
Creatine metabolism (7) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (19) REACT_111056
Cysteine formation from homocysteine (3) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (20) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (4) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
DNA methylation (1) REACT_267652
DNA replication initiation (1) REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (19) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (19) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Ethanol oxidation (2) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (9) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (20) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (4) REACT_1383
Glyoxylate metabolism (3) REACT_16925
HATs acetylate histones (1) REACT_172610
HDMs demethylate histones (2) REACT_228178
Hedgehog ligand biogenesis (1) REACT_228111
Heme biosynthesis (2) REACT_9465
Histidine catabolism (3) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (2) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (2) REACT_121120
Late Phase of HIV Life Cycle (1) REACT_6361
Ligand-gated ion channel transport (2) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (4) REACT_1298
Meiotic recombination (1) REACT_27271
Membrane binding and targetting of GAG proteins (1) REACT_115893
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Minus-strand DNA synthesis (1) REACT_9055
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (20) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (20) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (2) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (2) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (3) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (7) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
Plasmalogen biosynthesis (2) REACT_1407
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Processive synthesis on the C-strand of the telomere (1) REACT_8027
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (19) REACT_19328
Purine catabolism (7) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (6) REACT_21376
Pyrimidine catabolism (10) REACT_1023
Pyrimidine salvage reactions (7) REACT_655
Pyruvate metabolism (3) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (3) REACT_11042
Regulation by TREX1 (1) REACT_163652
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (1) REACT_22393
Reuptake of GABA (3) REACT_23910
RMTs methylate histone arginines (1) REACT_228108
RNA Polymerase I Transcription Initiation (1) REACT_953
Role of phospholipids in phagocytosis (1) REACT_160158
Scavenging by Class A Receptors (2) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (5) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Sialic acid metabolism (3) REACT_200874
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (3) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (5) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (10) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of PA (4) REACT_120906
Synthesis of PC (5) REACT_121238
Synthesis of PE (3) REACT_120919
Synthesis of PG (4) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Telomere C-strand synthesis initiation (1) REACT_7993
Telomere Extension By Telomerase (1) REACT_7974
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (2) REACT_15292
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (4) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (9) REACT_847
Utilization of Ketone Bodies (2) REACT_59
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin B5 (pantothenate) metabolism (1) REACT_11172
Vitamin C (ascorbate) metabolism (2) REACT_11202
WNT ligand biogenesis and trafficking (1) REACT_163710
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