ST001200 Biological Responses to Tobacco Smoke Exposure in III Children: Inflammatory Processes and the Oral Microbiome
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abnormal metabolism in phenylketonuria (1) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (8) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (5) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (5) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (1) REACT_197
Ca2+ pathway (1) REACT_172761
cGMP effects (1) REACT_23767
Circadian Clock (2) REACT_24941
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (5) REACT_111056
Cytosolic tRNA aminoacylation (5) REACT_15306
Degradation of GABA (1) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (1) REACT_9518
Endosomal/Vacuolar pathway (5) REACT_111168
eNOS activation (3) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (5) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (4) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (6) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (1) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (6) REACT_6960
Glyoxylate metabolism (1) REACT_16925
Histamine receptors (1) REACT_16903
Histidine catabolism (3) REACT_1249
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Keratan sulfate biosynthesis (1) REACT_121120
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (1) REACT_14820
Miscellaneous substrates (1) REACT_13425
Mitochondrial tRNA aminoacylation (5) REACT_15302
mRNA Capping (1) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (6) REACT_20506
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transporters (1) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (2) REACT_267716
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (2) REACT_116145
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Proton/oligonucleotide cotransporters (5) REACT_19328
Purine catabolism (2) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (1) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
RORA activates circadian gene expression (2) REACT_118659
Scavenging by Class A Receptors (1) REACT_163699
Serine biosynthesis (1) REACT_115789
Sialic acid metabolism (1) REACT_200874
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (5) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of CL (1) REACT_120920
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PC (1) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (4) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
Termination of O-glycan biosynthesis (1) REACT_115835
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (3) REACT_23892
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleotide sugars (2) REACT_22151
Tryptophan catabolism (2) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (4) REACT_847
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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