ST001279 K13 mutations driving artemisinin resistance rewrite Plasmodium falciparum’s programmed intra-erythrocytic development and transform mitochondrial physiology
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (4) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (2) REACT_160183
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (1) REACT_163932
Adenylate cyclase activating pathway (3) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (5) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amino acid synthesis and interconversion (transamination) (10) REACT_238
Amino acid transport across the plasma membrane (14) REACT_13796
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (14) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (14) REACT_75842
ARMS-mediated activation (1) REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (2) REACT_121408
Attenuation phase (1) REACT_200624
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Axonal growth stimulation (1) REACT_13779
Beta oxidation of butanoyl-CoA to acetyl-CoA (2) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (3) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (3) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (3) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (3) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (3) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (3) REACT_2025
Beta-oxidation of pristanoyl-CoA (3) REACT_17017
Beta-oxidation of very long chain fatty acids (3) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (2) REACT_22433
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (5) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
Cell redox homeostasis (3) REACT_121394
Cholesterol biosynthesis (5) REACT_9405
Chondroitin sulfate biosynthesis (2) REACT_120989
Citric acid cycle (TCA cycle) (7) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (4) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (1) REACT_6867
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (2) REACT_20625
Cross-presentation of particulate exogenous antigens (phagosomes) (1) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (13) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic iron-sulfur cluster assembly (2) REACT_160176
Cytosolic tRNA aminoacylation (14) REACT_15306
DAP12 signaling (1) REACT_147814
DARPP-32 events (1) REACT_15334
DCC mediated attractive signaling (1) REACT_22351
Defective B3GAT3 causes JDSSDHD (1) REACT_267659
Defective CHSY1 causes TPBS (1) REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1) REACT_267674
Defective EXT2 causes exostoses 2 (1) REACT_267654
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (2) REACT_172715
DNA replication initiation (1) REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Downstream signal transduction (1) REACT_17025
Downstream TCR signaling (1) REACT_12555
EGFR Transactivation by Gastrin (1) REACT_121096
Eicosanoids (1) REACT_13645
Electron transport from NADPH to Ferredoxin (2) REACT_150128
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (13) REACT_111168
eNOS activation (3) REACT_12477
Enzymatic degradation of dopamine by COMT (1) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (1) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (13) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (3) REACT_34
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FCERI mediated MAPK activation (1) REACT_163701
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (3) REACT_6737
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
Galactose catabolism (1) REACT_532
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (5) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (3) REACT_19327
G alpha (z) signalling events (3) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (3) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (8) REACT_1520
Glucuronidation (2) REACT_6784
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (14) REACT_6960
Glycogen synthesis (2) REACT_169208
Glycolysis (5) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (3) REACT_16925
Golgi Associated Vesicle Biogenesis (1) REACT_19400
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HATs acetylate histones (1) REACT_172610
HCN channels (1) REACT_75862
HDMs demethylate histones (1) REACT_228178
Hedgehog 'off' state (3) REACT_267634
Heme biosynthesis (2) REACT_9465
Heme degradation (3) REACT_22297
Histidine catabolism (2) REACT_1249
HIV Transcription Initiation (1) REACT_6332
HS-GAG biosynthesis (2) REACT_121248
HS-GAG degradation (2) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (3) REACT_163919
Inositol transporters (1) REACT_19188
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2) REACT_25367
Interconversion of polyamines (2) REACT_14805
Interleukin receptor SHC signaling (1) REACT_23891
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (1) REACT_121120
Kinesins (1) REACT_25201
Linoleic acid (LA) metabolism (3) REACT_121100
Lysine catabolism (4) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (6) REACT_1698
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (5) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Mineralocorticoid biosynthesis (2) REACT_11047
Minus-strand DNA synthesis (2) REACT_9055
Miscellaneous substrates (2) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (3) REACT_160
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (14) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (2) REACT_25073
MPS IIIC - Sanfilippo syndrome C (1) REACT_147860
mRNA Capping (1) REACT_1470
Mtb iron assimilation by chelation (1) REACT_121118
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (13) REACT_20506
NADPH regeneration (2) REACT_16904
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (4) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NOSIP mediated eNOS trafficking (1) REACT_12510
NOSTRIN mediated eNOS trafficking (1) REACT_12541
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
P2Y receptors (1) REACT_18289
p38MAPK events (1) REACT_12065
PAOs oxidise polyamines to amines (1) REACT_505
PD-1 signaling (1) REACT_19324
PDE3B signalling (1) REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Peptide chain elongation (1) REACT_1404
Peroxisomal lipid metabolism (1) REACT_16957
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (5) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
PKA activation (2) REACT_15530
PKA activation in glucagon signalling (2) REACT_1946
Plasmalogen biosynthesis (2) REACT_1407
Platelet degranulation (2) REACT_318
PLC beta mediated events (1) REACT_15426
Pregnenolone biosynthesis (1) REACT_11038
Pre-NOTCH Processing in Golgi (1) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (2) REACT_118722
Processive synthesis on the C-strand of the telomere (1) REACT_8027
Proline catabolism (3) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (13) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (5) REACT_2071
Rap1 signalling (3) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (2) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of pyruvate dehydrogenase (PDH) complex (3) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Regulation of thyroid hormone activity (1) REACT_15297
Removal of DNA patch containing abasic residue (1) REACT_2192
Resolution of AP sites via the single-nucleotide replacement pathway (1) REACT_933
Resolution of Sister Chromatid Cohesion (2) REACT_150425
Respiratory electron transport (2) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (1) REACT_24968
Retrograde neurotrophin signalling (1) REACT_12435
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
RNA Polymerase II HIV Promoter Escape (1) REACT_6253
RNA Polymerase II Promoter Escape (1) REACT_2089
RNA Polymerase II Transcription Initiation (1) REACT_1851
RNA Polymerase I Transcription Initiation (1) REACT_953
Scavenging by Class A Receptors (1) REACT_163699
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Separation of Sister Chromatids (2) REACT_150471
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Sialic acid metabolism (3) REACT_200874
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (3) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1) REACT_13438
Stimuli-sensing channels (1) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (4) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (8) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (3) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of Dolichyl-phosphate (3) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (2) REACT_150352
Synthesis of Ketone Bodies (2) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of Lipoxins (LX) (2) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Telomere C-strand synthesis initiation (1) REACT_7993
Telomere Extension By Telomerase (1) REACT_7974
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (3) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The proton buffering model (1) REACT_6196
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (2) REACT_15292
Tie2 Signaling (1) REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport and synthesis of PAPS (1) REACT_6840
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Transport of vitamins, nucleosides, and related molecules (2) REACT_22285
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (3) REACT_160111
Uptake and function of anthrax toxins (2) REACT_228255
Urea cycle (6) REACT_847
Utilization of Ketone Bodies (2) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (3) REACT_24023
VEGFA-VEGFR2 Pathway (3) REACT_228166
VEGFR2 mediated vascular permeability (3) REACT_228016
Vitamin B2 (riboflavin) metabolism (3) REACT_11070
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
Xenobiotics (1) REACT_13543
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