ST001280 Macrophage-Mediated Clofazimine Sequestration is Accompanied by a Shift in Host Energy Metabolism
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (2) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (1) REACT_238
Amino acid transport across the plasma membrane (6) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (4) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (4) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Branched-chain amino acid catabolism (1) REACT_197
Carnitine synthesis (3) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (4) REACT_111056
Cytosolic tRNA aminoacylation (4) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (2) REACT_23964
Endosomal/Vacuolar pathway (4) REACT_111168
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (4) REACT_111178
Ethanol oxidation (1) REACT_34
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
FMO oxidises nucleophiles (2) REACT_13653
Free fatty acid receptors (1) REACT_21268
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (1) REACT_18283
Gluconeogenesis (2) REACT_1520
Glutathione synthesis and recycling (4) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
HS-GAG biosynthesis (1) REACT_121248
Hydrolysis of LPC (1) REACT_120977
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Ligand-gated ion channel transport (1) REACT_25387
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Methionine salvage pathway (1) REACT_75881
Methylation (1) REACT_6946
Mitochondrial tRNA aminoacylation (4) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (6) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinamide salvaging (1) REACT_11213
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (3) REACT_22357
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
Passive transport by Aquaporins (1) REACT_23826
Phenylalanine and tyrosine catabolism (3) REACT_1786
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (4) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (1) REACT_1776
Pyrimidine catabolism (1) REACT_1023
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Reuptake of GABA (1) REACT_23910
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (1) REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sulfur amino acid metabolism (4) REACT_115639
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of PS (1) REACT_120823
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The fatty acid cycling model (1) REACT_6258
Thyroxine biosynthesis (1) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Tryptophan catabolism (2) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (1) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vitamin C (ascorbate) metabolism (1) REACT_11202
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