ST001610 Control (DMSO 0.1%; v/v) and 10 µM DRB18 treated A549 lung cancer cells in vitro for 48 hours
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (2) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (4) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (5) REACT_238
Amino acid transport across the plasma membrane (8) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Attenuation phase (1) REACT_200624
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (3) REACT_197
Carnitine synthesis (2) REACT_2125
Cell redox homeostasis (1) REACT_121394
Cholesterol biosynthesis (2) REACT_9405
Chondroitin sulfate biosynthesis (1) REACT_120989
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of particulate exogenous antigens (phagosomes) (1) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (9) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic tRNA aminoacylation (9) REACT_15306
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC (1) REACT_169169
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of GABA (1) REACT_23964
Detoxification of Reactive Oxygen Species (2) REACT_172715
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (1) REACT_9518
DNA replication initiation (2) REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Eicosanoids (1) REACT_13645
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (9) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (9) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (1) REACT_34
Fatty acids (1) REACT_13814
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FMO oxidises nucleophiles (1) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (4) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (10) REACT_6960
Glycogen synthesis (2) REACT_169208
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (3) REACT_16925
HATs acetylate histones (1) REACT_172610
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (1) REACT_9465
Heme degradation (2) REACT_22297
Histidine catabolism (1) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (2) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (2) REACT_11082
Interconversion of polyamines (2) REACT_14805
Iron uptake and transport (1) REACT_25060
Keratan sulfate biosynthesis (1) REACT_121120
Leukotriene receptors (1) REACT_18302
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Metabolism of nucleotides (2) REACT_1698
Metabolism of polyamines (1) REACT_14820
Methylation (2) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Minus-strand DNA synthesis (2) REACT_9055
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial tRNA aminoacylation (9) REACT_15302
MPS IIIC - Sanfilippo syndrome C (1) REACT_147860
Mtb iron assimilation by chelation (1) REACT_121118
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
NADPH regeneration (1) REACT_16904
NGF-independant TRKA activation (1) REACT_11046
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (1) REACT_22310
Organic anion transporters (3) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
P2Y receptors (2) REACT_18289
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Peroxisomal lipid metabolism (1) REACT_16957
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Plasmalogen biosynthesis (2) REACT_1407
Pregnenolone biosynthesis (1) REACT_11038
Pre-NOTCH Processing in Golgi (1) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Processive synthesis on the C-strand of the telomere (2) REACT_8027
Proline catabolism (1) REACT_1002
Prostanoid ligand receptors (1) REACT_18425
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (9) REACT_19328
Purine catabolism (6) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (3) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (2) REACT_12528
Regulation of thyroid hormone activity (1) REACT_15297
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (1) REACT_24968
RNA Polymerase I Transcription Initiation (1) REACT_953
Scavenging by Class A Receptors (1) REACT_163699
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (2) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1) REACT_13438
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (9) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (2) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (4) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (4) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Telomere C-strand synthesis initiation (2) REACT_7993
Telomere Extension By Telomerase (2) REACT_7974
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3) REACT_1206
Transport of organic anions (1) REACT_23988
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (2) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
Utilization of Ketone Bodies (3) REACT_59
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
Xenobiotics (1) REACT_13543
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