ST001856 The metabolomic resetting effect of FG4592 in AKI to CKD transition-day 21 (Part 2)
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (4) REACT_121388
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of gene expression by SREBF (SREBP) (3) REACT_147904
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (2) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1) REACT_19180
Adrenoceptors (1) REACT_16927
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (2) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (21) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (15) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (16) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Arachidonic acid metabolism (1) REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (3) REACT_111118
Branched-chain amino acid catabolism (4) REACT_197
Ca2+ pathway (2) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Catecholamine biosynthesis (4) REACT_15551
Cell redox homeostasis (1) REACT_121394
cGMP effects (2) REACT_23767
Cholesterol biosynthesis (1) REACT_9405
Circadian Clock (3) REACT_24941
Citric acid cycle (TCA cycle) (4) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (6) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (5) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COX reactions (1) REACT_1396
Creatine metabolism (6) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (15) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic iron-sulfur cluster assembly (2) REACT_160176
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (16) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (3) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (3) REACT_115654
Degradation of GABA (1) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (2) REACT_9472
Digestion of dietary lipid (3) REACT_9518
DNA methylation (2) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Eicosanoid ligand-binding receptors (1) REACT_18352
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (4) REACT_13812
Endosomal/Vacuolar pathway (15) REACT_111168
eNOS activation (5) REACT_12477
Enzymatic degradation of dopamine by COMT (3) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (2) REACT_15511
ER-Phagosome pathway (15) REACT_111178
ER Quality Control Compartment (ERQC) (1) REACT_25091
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (4) REACT_1319
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (1) REACT_13653
formation of the beta-catenin:TCF transactivating complex (2) REACT_200753
Free fatty acid receptors (5) REACT_21268
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (1) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (9) REACT_18283
G alpha (s) signalling events (7) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (5) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (17) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (3) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (2) REACT_9465
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histidine catabolism (1) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
Hydrolysis of LPC (1) REACT_120977
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (2) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (2) REACT_14805
Iron uptake and transport (1) REACT_25060
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (3) REACT_1298
Meiotic recombination (2) REACT_27271
Metabolism of folate and pterines (1) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (4) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (6) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (3) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial tRNA aminoacylation (16) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (3) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (20) REACT_20506
Na+-dependent glucose transporters (1) REACT_19165
Neurotransmitter Clearance In The Synaptic Cleft (3) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
NoRC negatively regulates rRNA expression (2) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (2) REACT_15418
NOSIP mediated eNOS trafficking (2) REACT_12510
NOSTRIN mediated eNOS trafficking (2) REACT_12541
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Organic cation transport (5) REACT_22357
Orphan transporters (7) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
PAOs oxidise polyamines to amines (2) REACT_505
PDE3B signalling (1) REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2) REACT_150237
phospho-PLA2 pathway (1) REACT_15466
Plasmalogen biosynthesis (3) REACT_1407
PPARA activates gene expression (5) REACT_116145
PRC2 methylates histones and DNA (2) REACT_200808
Pre-NOTCH Processing in Golgi (1) REACT_118798
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1) REACT_25396
Proline catabolism (2) REACT_1002
Prostanoid ligand receptors (2) REACT_18425
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (15) REACT_19328
Purine catabolism (14) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (12) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (11) REACT_1023
Pyrimidine salvage reactions (9) REACT_655
Pyruvate metabolism (1) REACT_2071
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recycling of bile acids and salts (4) REACT_11042
Regulation by TREX1 (1) REACT_163652
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (3) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (2) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Respiratory electron transport (3) REACT_22393
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (4) REACT_24968
Reuptake of GABA (3) REACT_23910
REV-ERBA represses gene expression (3) REACT_118789
RMTs methylate histone arginines (2) REACT_228108
Role of phospholipids in phagocytosis (2) REACT_160158
RORA activates circadian gene expression (3) REACT_118659
Scavenging by Class A Receptors (3) REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (6) REACT_115810
Stimuli-sensing channels (2) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (9) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (7) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (2) REACT_150209
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (2) REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (5) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (7) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
Termination of O-glycan biosynthesis (1) REACT_115835
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (3) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (4) REACT_160156
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thyroxine biosynthesis (2) REACT_15292
Transcriptional activation of mitochondrial biogenesis (3) REACT_200608
Transcriptional regulation of white adipocyte differentiation (3) REACT_27161
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of fatty acids (5) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (13) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Transport of organic anions (3) REACT_23988
Tryptophan catabolism (3) REACT_916
Ubiquinol biosynthesis (3) REACT_160111
Urea cycle (5) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (4) REACT_228016
Vitamin B1 (thiamin) metabolism (2) REACT_11117
Vitamin B2 (riboflavin) metabolism (3) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (4) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (3) REACT_118713
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