ST001897 A local source of insulin in the eye governed by phagocytosis and starvation
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (6) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (3) REACT_228214
Agmatine biosynthesis (4) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (6) REACT_238
Amino acid transport across the plasma membrane (19) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (18) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (4) REACT_197
Ca2+ pathway (1) REACT_172761
Carnitine synthesis (5) REACT_2125
Catecholamine biosynthesis (5) REACT_15551
Cell redox homeostasis (1) REACT_121394
cGMP effects (1) REACT_23767
Cholesterol biosynthesis (1) REACT_9405
Chondroitin sulfate biosynthesis (1) REACT_120989
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cleavage of the damaged purine (2) REACT_1729
Cleavage of the damaged pyrimidine (3) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (3) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (5) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic sulfonation of small molecules (3) REACT_6913
Cytosolic tRNA aminoacylation (18) REACT_15306
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
degradation of AXIN (2) REACT_200766
Degradation of cysteine and homocysteine (4) REACT_115654
Degradation of GABA (3) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
DNA methylation (1) REACT_267652
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (2) REACT_121111
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (18) REACT_111168
eNOS activation (2) REACT_12477
Enzymatic degradation of dopamine by COMT (2) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1) REACT_15511
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (18) REACT_111178
Ethanol oxidation (1) REACT_34
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
FMO oxidises nucleophiles (1) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
GABA synthesis (1) REACT_24020
Galactose catabolism (1) REACT_532
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (5) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (4) REACT_1520
Glucuronidation (2) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (20) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (1) REACT_1383
Glycosphingolipid metabolism (3) REACT_116105
Glyoxylate metabolism (2) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme biosynthesis (1) REACT_9465
Heme degradation (1) REACT_22297
Histamine receptors (1) REACT_16903
Histidine catabolism (5) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPC (2) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Hypusine synthesis from eIF5A-lysine (3) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (2) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of polyamines (3) REACT_14805
Iron uptake and transport (1) REACT_25060
Keratan sulfate biosynthesis (2) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (3) REACT_1298
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (3) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (4) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (4) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (1) REACT_13425
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (18) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
mRNA Capping (2) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (20) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (3) REACT_11213
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (9) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
P2Y receptors (1) REACT_18289
PAOs oxidise polyamines to amines (3) REACT_505
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (6) REACT_1786
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in Golgi (2) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (3) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (18) REACT_19328
Purine catabolism (9) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (6) REACT_1776
Purine salvage (8) REACT_1923
Pyrimidine biosynthesis (5) REACT_21376
Pyrimidine catabolism (10) REACT_1023
Pyrimidine salvage reactions (7) REACT_655
Pyruvate metabolism (2) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation by TREX1 (1) REACT_163652
Regulation of HSF1-mediated heat shock response (2) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Respiratory electron transport (1) REACT_22393
Retinoid cycle disease events (1) REACT_160130
Reuptake of GABA (1) REACT_23910
RMTs methylate histone arginines (1) REACT_228108
Role of phospholipids in phagocytosis (1) REACT_160158
Scavenging by Class A Receptors (2) REACT_163699
Scavenging by Class B Receptors (1) REACT_163679
Scavenging by Class F Receptors (1) REACT_163813
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Sialic acid metabolism (2) REACT_200874
SIRT1 negatively regulates rRNA Expression (3) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (5) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (7) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (8) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (3) REACT_120906
Synthesis of PC (3) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (2) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (11) REACT_1206
Transport of nucleotide sugars (2) REACT_22151
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (7) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (6) REACT_847
Utilization of Ketone Bodies (2) REACT_59
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin C (ascorbate) metabolism (3) REACT_11202
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (2) REACT_25012
Xenobiotics (1) REACT_13543
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