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ST002094 Commensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 1)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (2)
REACT_121388
Abacavir transmembrane transport (1)
REACT_120801
ABH2 mediated Reversal of Alkylation Damage (1)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (1)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Acetylation (4)
REACT_6732
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of gene expression by SREBF (SREBP) (1)
REACT_147904
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Adrenaline,noradrenaline inhibits insulin secretion (1)
REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1)
REACT_19180
Adrenoceptors (1)
REACT_16927
Aflatoxin activation and detoxification (1)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
Alpha-oxidation of phytanate (2)
REACT_17003
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (11)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (8)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1)
REACT_111118
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (3)
REACT_15551
Cholesterol biosynthesis (1)
REACT_9405
Circadian Clock (1)
REACT_24941
Citric acid cycle (TCA cycle) (3)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (10)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (3)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (1)
REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (8)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (4)
REACT_6913
Cytosolic tRNA aminoacylation (8)
REACT_15306
Defective HLCS causes multiple carboxylase deficiency (1)
REACT_169312
Degradation of cysteine and homocysteine (3)
REACT_115654
Degradation of GABA (1)
REACT_23964
Digestion of dietary carbohydrate (1)
REACT_9472
Digestion of dietary lipid (1)
REACT_9518
DNA replication initiation (1)
REACT_2244
Dopamine clearance from the synaptic cleft (1)
REACT_15514
Dopamine Neurotransmitter Release Cycle (1)
REACT_15293
Dopamine receptors (1)
REACT_16968
Eicosanoids (1)
REACT_13645
Endosomal/Vacuolar pathway (8)
REACT_111168
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
ER-Phagosome pathway (8)
REACT_111178
Ethanol oxidation (1)
REACT_34
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
Free fatty acid receptors (2)
REACT_21268
G alpha (12/13) signalling events (1)
REACT_18407
G alpha (i) signalling events (14)
REACT_19231
G alpha (q) signalling events (8)
REACT_18283
G alpha (s) signalling events (4)
REACT_19327
G alpha (z) signalling events (1)
REACT_19333
Gluconeogenesis (2)
REACT_1520
Glucuronidation (2)
REACT_6784
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (8)
REACT_6960
Glyoxylate metabolism (2)
REACT_16925
HDMs demethylate histones (1)
REACT_228178
Heme biosynthesis (2)
REACT_9465
Heme degradation (1)
REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histamine receptors (1)
REACT_16903
Histidine catabolism (2)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
HS-GAG biosynthesis (1)
REACT_121248
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
Interconversion of polyamines (3)
REACT_14805
Iron uptake and transport (1)
REACT_25060
Keratan sulfate biosynthesis (1)
REACT_121120
Leukotriene receptors (1)
REACT_18302
Ligand-gated ion channel transport (1)
REACT_25387
Lysine catabolism (3)
REACT_1298
Lysosphingolipid and LPA receptors (1)
REACT_18365
Metabolism of Angiotensinogen to Angiotensins (1)
REACT_147707
Metabolism of folate and pterines (1)
REACT_11167
Metabolism of nucleotides (1)
REACT_1698
Metabolism of polyamines (3)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (4)
REACT_6946
Minus-strand DNA synthesis (1)
REACT_9055
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (8)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (14)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (1)
REACT_11088
NoRC negatively regulates rRNA expression (1)
REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
Organic anion transport (4)
REACT_22310
Organic anion transporters (3)
REACT_19372
Organic cation transport (8)
REACT_22357
Orphan transporters (1)
REACT_267716
Oxidative Stress Induced Senescence (1)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1)
REACT_120916
PAOs oxidise polyamines to amines (3)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
Phenylalanine and tyrosine catabolism (2)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
Platelet degranulation (1)
REACT_318
PPARA activates gene expression (2)
REACT_116145
Pre-NOTCH Processing in Golgi (1)
REACT_118798
Processive synthesis on the C-strand of the telomere (1)
REACT_8027
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (8)
REACT_19328
Purine catabolism (5)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1)
REACT_1776
Purine salvage (5)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (6)
REACT_1023
Pyrimidine salvage reactions (4)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Recycling of bile acids and salts (1)
REACT_11042
Regulation by TREX1 (1)
REACT_163652
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1)
REACT_19241
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (1)
REACT_118789
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (1)
REACT_118659
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (3)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
Sialic acid metabolism (1)
REACT_200874
Signaling by constitutively active EGFR (1)
REACT_115852
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (3)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (2)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (3)
REACT_21330
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of Dolichyl-phosphate (1)
REACT_22230
Synthesis of glycosylphosphatidylinositol (GPI) (1)
REACT_952
Synthesis of Ketone Bodies (1)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PE (1)
REACT_120919
Synthesis of PG (2)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4)
REACT_150149
Synthesis of PS (3)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1)
REACT_23824
Telomere C-strand synthesis initiation (1)
REACT_7993
Telomere Extension By Telomerase (1)
REACT_7974
Termination of O-glycan biosynthesis (1)
REACT_115835
TET1,2,3 and TDG demethylate DNA (1)
REACT_200682
Thyroxine biosynthesis (1)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (1)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9)
REACT_1206
Transport of nucleotide sugars (1)
REACT_22151
Transport of organic anions (1)
REACT_23988
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (5)
REACT_916
Urea cycle (1)
REACT_847
Utilization of Ketone Bodies (2)
REACT_59
VEGFR2 mediated cell proliferation (1)
REACT_228024
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
Vitamins B6 activation to pyridoxal phosphate (2)
REACT_25012
Xenobiotics (5)
REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1)
REACT_118713
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